ISSN:
1435-1463
Keywords:
Cobalt-induced epilepsy
;
rat cerebral cortex
;
noradrenaline
;
ionophoresis
;
adrenoceptor binding
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Several studies indicate that brain noradrenaline (NA) depletion facilitates the occurrence of epileptogenic syndromes in various animal models. In cobalt-induced epilepsy in the rat, seizure activity is associated with a cortical NA denervation. In order to search for cortical adrenoceptor modifications, inonophoretic studies and adrenoceptor binding assays were performed. At the period of maximal seizure activity, there was a significant supersensitivity of cortical neurons to the ionophoretic application of NA. An increase in the density ofβ-adrenoceptor binding sites was observed. No modification inα 1- andα 2-adrenoceptor binding sites was found. This suggests that in cobalt-induced epilepsy there is a denervation supersensitivity which rests on a selective involvement ofβ-adrenoceptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01252611
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