ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Synthesis of Stereisomeric Pinanthromboxane Derivatives and Evaluation of the Compounds as Platelet Aggregation InhibitorsStarting from the two enantiomeric myrtenols ((-)-1 and (+)-1; cf. Scheme 1), the synthesis of twelve stereoisomeric pinanthromboxane derivatives ((+)- and (-)-10, -11, -14, -15, -21 and -22) is described (cf. Schemes 1-4). Biological data from the evaluation as platelet aggregation inhibitors (cf. Table 6 and 7), thromboxane synthetase inhibitors (cf. Table 8) and from the assessment as antagonists of leukotriene E4 induced bronchoconstriction (cf. Table 9) are presented.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19830660331
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