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  • 1
    Digitale Medien
    Digitale Medien
    Transient Increase of Cyclic AMP Induced by Glutamate in Cultured Neurons from Rat Spinal Cord (1995)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 65 (1995), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: We demonstrated that glutamate increased the cyclic AMP level in cultured neurons from rat spinal cord. A bath application of glutamate (300 µM) elicited a rapid increase of the cyclic AMP concentration reaching a level three times as high as the basal level in ∼3 min, and its content then decreased to the control level in 15 min. The increase was not observed in a Ca2+-free medium and was inhibited by an antagonist of NMDA receptors or a voltage-sensitive Ca2+ channel blocker. Preincubation with W7 also inhibited the glutamate-evoked cyclic AMP increase. NMDA, aspartate, and high-K+ conditions also induced a cyclic AMP increase; however, a decreasing phase did not follow. The decreasing phase was observed when (2S,1′S,2′S)-2-(carboxycyclopropyl)-glycine, a potent agonist for metabotropic glutamate receptors, was combined with NMDA. These results suggest that the cyclic AMP increase is mediated by a Ca2+ influx via both NMDA receptors and voltage-sensitive Ca2+ channels followed by an activation of the Ca2+/calmodulin system, and the decreasing phase observed in the case of glutamate exposure is due to the activation of the metabotropic glutamate receptors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1471-4159.1995.65041816.x
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  • 2
    Digitale Medien
    Digitale Medien
    Infrared optical constants and absorption intensities of naphthalene single crystal (1972)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 76 (1972), S. 260-269 
    Details
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/j100646a021
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  • 3
    Digitale Medien
    Digitale Medien
    IBUDILAST PROTECTS AGAINST NEURONAL DAMAGE INDUCED BY GLUTAMATE IN CULTURED HIPPOCAMPAL NEURONS (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 23 (1996), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. The effect of ibudilast, a drug that has been clinically used for asthma and the improvement of cerebrovascular disorders, was examined on glutamate neurotoxicity in cultured neurons from rat hippocampus.2. The extent of neuronal damage induced by exposure of the neurons to glutamate for 5 min was estimated by the activity of lactate dehydrogenase (LDH) released from degenerated neurons into the medium during a 24 h postexposure period. When ibudilast was added into all pre-incubation, exposure and postexposure media, the extent of neuronal damage decreased to approximately half that of control at an ibudilast concentration of 43 μmol/L.3. The neuroprotective effects of ibudilast were dose-dependent. Sufficient protection was detected even when ibudilast was added only into the postexposure medium.4. The extent of 45Ca2+ influx during glutamate exposure was slightly reduced by the addition of ibudilast. Intracellular cAMP, as measured by radioimmunoassay, was increased by neuronal exposure to glutamate and then decreased after the removal of glutamate; however in the presence of ibudilast, AMP was maintained at the high level.5. These results suggest that protection against glutamate neurotoxicity by ibudilast is not only attributable to the inhibition of phenomena that occur during glutamate exposure, such as Ca2+ influx, but also to some beneficial metabolic changes that are induced by a sustained high level of intracellular cAMP.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1996.tb02772.x
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  • 4
    Digitale Medien
    Digitale Medien
    XAFS study on the sulfidation mechanisms of Co–Mo catalysts supported on activated carbon and alumina: effect of complexing agent (2001)
    Chester : International Union of Crystallography (IUCr)
    Journal of synchrotron radiation 8 (2001), S. 651-653 
    Details
    ISSN: 1600-5775
    Quelle: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Thema: Geologie und Paläontologie , Physik
    Notizen: The effect of nitrilotriacetic acid (NTA) as a complexing agent on the sulfidation mechanisms of Co-Mo catalysts supported on activated carbon and alumina was examined by the XAFS technique. The XAFS results revealed that NTA interacted with Co atoms and formed the Co-NTA interaction, while it showed almost no influence on the local structures around Mo atoms. The Co-NTA interaction suppressed the aggregation of cobalt atoms and the interaction between cobalt and alumina during sulfiding, and consequently promoted the formation of the Co-Mo-S phase.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1107/S0909049500018641
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  • 5
    Digitale Medien
    Digitale Medien
    EXAFS characterization of bimetallic Pt–Pd/SiO2–Al2O3 catalysts for hydrogenation of aromatics in diesel fuel (1999)
    Springer
    Catalysis letters 63 (1999), S. 27-33 
    Details
    ISSN: 1572-879X
    Schlagwort(e): Pt–Pd bimetallic catalysts ; aromatic hydrogenation ; diesel fuel ; EXAFS ; active site ; Pd species dispersed on Pt particle
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Bimetallic Pt–Pd/SiO2–Al2O3 catalysts exhibited much higher activities in aromatic hydrogenation of distillates than monometallic Pt/SiO2–Al2O3 and Pd/SiO2–Al2O3 catalysts. The studies of extended X‐ray absorption fine structure (EXAFS) indicated that there was an interaction between Pt and Pd in the Pt–Pd/ SiO2–Al2O3 catalyst. Furthermore, from the EXAFS, it was assumed that the active metal particle on the Pt–Pd/SiO2–Al2O3 catalysts is composed of the “Pd dispersed on Pt particle” structure. Regarding both the activities of aromatic hydrogenation and the EXAFS results, it was concluded that the Pd species dispersed on Pt particles were responsible for the high activity of the bimetallic Pt–Pd/SiO2–Al2O3 catalysts.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1019008803028
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  • 6
    Digitale Medien
    Digitale Medien
    A possible mechanism for the hypoxia-hypoglycemia-induced release of excitatory amino acids from cultured hippocampal astrocytes (1995)
    Springer
    Neurochemical research 20 (1995), S. 737-743 
    Details
    ISSN: 1573-6903
    Schlagwort(e): Aspartate ; glutamate ; ischemic brain injury
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In order to elucidate the mechanism of release of excitatory amino acid (EAA) induced by hypoxiahypoglycemia (in vitro ischemia) from cultured hippocampal astrocytes, we compared the EAA release by in vitro ischemia with those by other treatments. The EAA release induced by in vitro ischemia treatment was rapid and reversible. The amount of released aspartate was comparable to that of glutamate, although the endogenous content of aspartate was one sixth that of glutamate. High-K (100 mM) treatment and the addition of 5 mM NaCN induced a rapid EAA release and the glutamate release was much greater than aspartate. Addition of 5 mM iodoacetate, a glycolysis inhibitor, induced a slow EAA release, and the amount of released aspartate was much higher than that of glutamate. On the other hand, the in vitro ischemia treatment and the addition of 5 mM NaCN induced only 20% reduction in ATP content for initial 5 min, whereas the addition of 5 mM iodiacetate induced a marked reduction. Our data suggest that ischemia-induced EAA release from astrocytes is a complex process in which local energy failure, inhibition of glycolysis, and depolarization of the cell membrane are involved.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01705543
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  • 7
    Digitale Medien
    Digitale Medien
    Origin of cultivated Tatary buckwheat (Fagopyrum tataricum Gaertn.) revealed by RAPD analyses (2000)
    Springer
    Genetic resources and crop evolution 47 (2000), S. 431-438 
    Details
    ISSN: 1573-5109
    Schlagwort(e): cultivated Tatary buckwheat ; origin ; RAPD markers ; wild Tatary buckwheat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Abstract The phylogenetic relationships among cultivated landraces and natural populations of wild subspecies of Tatary buckwheat were investigated at the individual level by constructing a phylogenetic tree based on RAPD markers. As the PCR templates, DNA of individuals rather than bulked samples, was used. Ten individuals from 10 cultivated landraces, 71 individuals from 21 natural populations of wild subspecies, and 7 individuals from 3 weedy Tatary buckwheat were provided for RAPD analyses. Three groups were recognized: (1) all cultivated landraces and wild subspecies from central Tibet and northern Pakistan; (2) 10 individuals of wild subspecies from northwestern Yunnan; (3) the remaining individuals of wild subspecies from northwestern Yunnan and all individuals of wild subspecies from Sichuan. Group (2) was phylogenetically closely related to group (1). The origin of cultivated Tatary buckwheat, the hybrid origin of weedy Tatary buckwheat and of the wild populations from central Tibet and northern Pakistan are discussed. We arrive at the conclusion that cultivated Tatary buckwheat probably originated in northwestern Yunnan in China.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1008741513277
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