ISSN:
0265-9247
Keywords:
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Medicine
Notes:
The last year has unveiled extensive information on the T-cell antigen receptor genes. For both the α- and β-chains of this molecule, it is clear that an expressed gene is compiled from several coding sequences dispersed along the chromosome. During T-cell development, recombination events occur which create a single transcription unit from these dispersed elements. Such gene organization shows that the T-cell receptor has close evolutionary links with immunoglobulins. Both types of molecule use the same genetic mechanisms to create the diversity necessary for antigen recognition.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bies.950020408
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