ISSN:
1573-8353
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The sequences of the change in the relative rates of the formylation and acetylation of o-methoxybenzodioxaheterocycles, and 1,2,3-trimethoxybenzene were established by the method of competitive reactions. It was shown that 4-methoxybenzo-1,3-dioxolane forms primarily 5-acyl derivatives, while 5-methoxybenzo-1,4-dioxane and 6-methoxybenzo-1,5-dioxepane form primarily 8- and 9-acyl derivatives, respectively. The acetyl derivatives were converted via the Mannich reaction to hydrochlorides of β-dimethylaminopropionyl derivatives, which have anti-inflammatory activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00506607
Permalink