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  • 1
    Electronic Resource
    Electronic Resource
    The relationship between HTLV-I-infected cell lines and uveitis (1995)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 233 (1995), S. 231-235 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract • Background: Recently it has been revealed that human T-lymphotropic virus type I (HTLV-I) infection causes uveitis in human. We previously reported HTLV-I uveitis in a rabbit. To investigate the relationship between HTLV-I infection and uveitis, we established an HTLV-I-infected T-cell clone from the cells infiltrated in the anterior chamber of this rabbit and compared the viral production with that in other HTLV-I-infected cell lines. • Methods: The clonality was determined by Southern blot hybridization with various restriction enzymes. Flow-cytometric analysis was used for investigating the expression of cell surface antigens. To compare viral production, we performed reverse transcriptase assay of the culture media and inhibition enzyme-linked immunosorbent assay to determine the quantity of intracellular HTLV-I antigens. • Results: The established clone was Ia (MHC class II) positive T cell. This T-cell clone was able to produce about three times more HTLV-I antigens than other HTLV-I-infected cell lines tested. • Conclusion: A T-cell clone established from anterior aqueous of an HTLV-I uveitis rabbit can produce more HTLV-I antigen than other HTLV-I-infected cell lines tested and it can be recognized easily by the immune system. Therefore, this high virus production may have a causal relation to uveitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00183597
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  • 2
    Electronic Resource
    Electronic Resource
    Ameloblastoma of the mandible metastasizing to the orbit with malignant transformation (1997)
    Springer
    Virchows Archiv 430 (1997), S. 501-507 
    Details
    ISSN: 1432-2307
    Keywords: Key words Ameloblastoma ; Metastasis ; Orbit ; Malignant transformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We report here a case of ameloblastoma of the mandible with multiple local recurrences and metastasis to the orbit. The patient was a 63-year-old Japanese woman with visual disturbance of her right eye. Diagnostic imaging revealed a mass occupying the right orbital apex with partial intracranial involvement. She had been surgically treated for mandibular ameloblastoma 27 years previously, and the tumour had recurred three times in the past 5 years. The orbital tumour and recurrent ameloblastomas were investigated histopathologically and immunohistochemically. The tumour changed in morphology as it recurred, from follicular ameloblastoma without atypia to apparent malignant tumours disclosing undifferentiated or squamoid features. On immunohistochemical analysis, staining for cytokeratin was positive in the squamoid cells but not in the undifferentiated cells. Both histopathologically and immunohistochemically, the orbital tumour was almost identical to the undifferentiated recurrent tumour. The orbital tumour was distinct from the primary site or sites of recurrence of ameloblastoma, and we concluded that the mandibular ameloblastoma underwent malignant transformation with multiple recurrences and finally metastasized to the orbit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050061
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Neurotransmitter contents in the retina of RCS rat (2000)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 238 (2000), S. 998-1001 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Background: Retinitis pigmentosa is a hereditary disease characterized by gradually developing degeneration of photoreceptors. The Royal College of Surgeons (RCS) rat is an experimental model of retinitis pigmentosa. However, there is a paucity of information concerning neurotransmitter contents in the retina of RCS rats. Thus, we determined the retinal contents of neurotransmitters in RCS rats at 4 and 23 weeks postnatally and in age-matched congenic control rats. Methods: Dopamine (DA) and acetylcholine (ACh) were electrochemically measured by high-performance liquid chromatography (HPLC). Neuroactive amino acids, including γ-aminobutyric acid (GABA) and taurine, were determined by means of an HPLC-precolumn derivatization method. Results: Contents of DA, ACh, glutamate, aspartate and GABA in the retina of RCS rats 4 weeks postnatally were within normal ranges. At 23 weeks, the retinal contents of DA, glutamate and aspartate in the RCS rats were significantly lower than in the age-matched control rats, while the contents of ACh and GABA were unaffected even at this later stage. On the other hand, the retinal content of glycine in the RCS rats at 23 weeks was significantly higher than that in the age-matched control rats. It is interesting to note that the content of taurine in the RCS rats had already decreased at 4 weeks postnatally and the decrease was more marked at 23 weeks. Conclusion: The decrease in taurine content is probably the first sign of degeneration revealed by the retinal neurotransmitters of RCS rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004170000215
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    Paper (German National Licenses)
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