ISSN:
1573-8221
Keywords:
dehydrogenases
;
ethanol
;
simulation of alcoholism
;
carbohydrate metabolism
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract It is shown that alcoholization of rats during 1.5 months by the inhalation of ethanol vapors with a long-term subsidence into narcotic sleep results in alcohol dependence and marked shifts in the ratio between the activity of malate and lactate dehydrogenases and a change in the isoenzyme spectrum of the latter. This leads to an enhancement of aerobic processes in the brain and skeletal muscle tissues and of anaerobic processes in the liver and myocardium. Semiforced alcoholization of rats during 11 months, with ethanol solution serving as the only soruce of liquid, moderately lowers the ethanol tolerance and does not affect the dehydrogenase activity in the tissues examined. The effects of ethanol on the activity of functionally associated enzyme systems of malate and lactate dehydrogenases are believed to depend on the method of alcoholization and the type of tissue.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02444391
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