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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Langmuir 7 (1991), S. 1546-1549 
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 6 (1984), S. 133-141 
    ISSN: 1279-8517
    Keywords: Embryology ; Internal carotid artery ; Agenesis ; External carotid artery ; Trigeminal artery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'étude de l'embryologie de la carotide interne montre qu' on peut la scinder en six segments consécutifs: cervical, pétreux, caverneux vertical, caverneux horizontal, clinoïdien, cisternal. Chacun d'eux a un trajet et des limites fixes, marqués par l'origine de vaisseaux embryonnaires particuliers: pharyngée ventrale, hyostapédienne, mandibulaire, maxillaire primitive, trijéminée, ophtalmique dorsale, ophtalmique ventrale. Chaque segment est indépendant et peut être agénétique; le flux carotidien est alors “dévié” par un autre chemin pour ce seul segment, après quoi, il retrouve la carotide interne stricto sensu dans son trajet habituel. Différentes agénésies segmentaires sont ainsi présentées: cervicale, pétreuse, caverneuse. Les “déviations” artérielles (cavité tympanique, fosse postérieure, côté opposé) et les vaisseaux embryonnaires objectivés (hyoïdienne, trijéminée, maxillaire primitive) permettent de caractériser de façon anatomiquement précise le défect artériel segmentaire et la solution hémodynamique qu'il a entraîné. On est dès lors capable de faire la différence entre une absence congénitale et acquise de la carotide interne, et celle qui sépare une disposition rare mais normale, prévisible et connue d'un aspect ignoré et considéré parfois à tort comme pathologique.
    Notes: Summary The embryology of the internal carotid artery (ICA) shows that this vessel comprises from origin to termination six segments, i.e. cervical, petrous, vertical cavernous, horizontal cavernous, clinoid and cisternal segments. Each of these segments displays a specific course and limits, defined by the origin of the following embryonic arteries: ventral pharyngeal hyoid, mandibular, primitive maxillary, trigeminal, dorsal ophthalmic and ventral ophthalmic. Each segment is independent and may show agenesis. In such cases the internal carotid blood flow (hemispheric arterial supply) is rerouted to afford usual ICA supply distal to the agenetic segment. All congenital anomalies of the ICA can be described and understood on the basis of embryological data. The “aberrant internal carotid” can therefore be identified as a normal vessel. Differentiation can be made between congenital versus acquired absence of the ICA. This type of analysis should allow the clinician to recognize what are normal, albeit rare variations, rather than to mistake them for an abnormal condition requiring treatment.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 6 (1984), S. 22-25 
    ISSN: 1279-8517
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion Il est clair que chaque solution hémodynamique développée pour compenser le segment agénétique ressemble à une disposition stable et classique d'une espèce connue (Bugge, 1974). Néanmoins, et comme le rappelle Vera (1977) dans sa thèse en citant Lazorthes et Gouazé: ≪ Les observations du réseau admirable chez l'homme ne correspondent en aucune manière à la persistance d'une disposition embryologique, mais représentent un dérapage lors du développement vers une disposition rencontrée chez certains mammifères au-dessous des primates ≫. Nous considérons que cette réflexion à propos du réseau admirable vaut pour toutes les variétés vasculaires en général et pour les agénésies de la carotide interne en particulier. Enfin aussi explicatif et intellectuellement satisfaisant que notre schéma puisse être, il comporte par définition un certain nombre d'imprécisions et peut-être d'inexactitudes, même si toutes les variétés de la carotide interne décrites à notre connaissance y sont réunies. En particulier si la représentation tubulaire des vaisseaux embryonnaires est pratique, on sait le caractère réticulé du système artériel avant que ne s'individualisent des voies privilégiées, les artères. La même analyse du caractère hétérogène de l'origine embryonnaire de l'artère vertébrale peut être décrite (Lasjaunias, 1983); elle aboutit à la compréhension de toutes les variétés anatomiques ≪ normales ≫ de cette artère dans la région cervicale haute.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1420-9071
    Keywords: Nicotiana suaveolens ; N. glutinosa ; interspecific hybrid ; glutamic-oxaloacetic-transaminase ; phosphoglucomutase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Two isozyme systems, phosphoglucomutase and glutamic-oxaloacetic-transaminase, have been studied in leaves ofNicotiana suaveolens, N. glutinosa and their interspecific hybrid. By analyzing the different isozyme patterns in the hybrid a model for the genetic control of these systems has been proposed. Phosphoglucomutase appears to be controlled by a single locus and glutamic-oxaloacetic-transaminase behaves as a dimeric isozyme system, being controlled by at least two loci.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1041
    Keywords: Molsidomine ; penbutolol ; angina pectoris ; angina severity scores ; ergometric tests ; betablocking agents ; pre-load reduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In order to test the additional efficacy of the combination of a beta blocker (penbutolol 40 mg single dose) with molsidomine (2 mg single dose), a double blind cross-over trial was performed in 30 patients with stable angina pectoris. Stress tests were done before and 1 h after the beta blocker alone and the combination therapy. Some training effect could be detected on comparing results from the first and second days. Combined therapy showed a better response of resting systolic arterial pressure, resting and maximal diastolic pressure, heart rate gain (from rest to maximal effort) and particularly in the angina severity score. All of these variables changed significantly in comparison to the beta blocker alone, 46 out of 60 post-drug ergometric studies were negative; of the 14 positive tests, 11 followed the beta blocker and only 3 the combined therapy. The combination of a preload reducer molsidomine and a beta blocker may be adequate for patients only partially compensated or with cardiomegaly and/or a depressed ejection fraction.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1041
    Keywords: molsidomine ; myocardial infarction ; haemodynamic effects ; pump failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Haemodynamic monitoring, using a Swan-Ganz balloon catheter, was done in 14 patients with pump failure associated with acute myocardial infarction, before and for 8 h after single 6 mg oral dose of molsidomine. The following changes effects were found: HR fell by 1.6 to 4.7% (significant at 4th hour; p〈0.05); SBP was 8.4% lower after 1 h (p〈0.05); PCP was decreased by approximately 30%, a significant effect that lasted for 8 hours (p〈0.002). CI did not change significantly, although individual analysis showed it to have increased in 6 out of 12 cases. Stroke volume index was increased by about 6% (significant after 1 h, p〈0.025). The left ventricular stroke work index also increased from 9.8 to 24.5% (significant after 1 and 4 h, p〈0.01 and 0.025). These findings show the beneficial haemodynamic effects of molsidomine in pump failure complicating acute myocardial infarction.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 13 (1978), S. 247-250 
    ISSN: 1432-1041
    Keywords: Molsidomine ; isosorbide dinitrate ; angina ; ECG analysis ; diastolic blood pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The antianginal activity of Molsidomine, a recently developed compound, was studied in 6 patients with stable angina pectoris who attended 3 trial sessions. On different days the patients received single doses of Molsidomine (M; 2 mg), isosorbide dinitrate (ISDN; 5 mg) or placebo (P), in a double blind cross-over manner. All patients performed exercise tests at time 0 (before medication) and 30, 60, 120, 240 and 360 min after drug intake. Tests were performed on a treadmill using the Bruce protocol; the ECG were recorded on 3 channel equipment and was stored on 2 channel magnetic tape (Holter system). No difference between basal values before treatment and on exercise during placebo were observed. At a similar submaximal workload after M and ISDN there was no significant change in heart rate or pressure-rate product, a decrease in systolic blood pressure, a reduction of ST ischemic response between 30 to 120 min after drug intake, and after M alone, a significant decrease in diastolic blood pressure during the 6 hour period. Molsidomine produced clear inhibition of exercise-evoked ischemic ST changes and a long-lasting effect on diastolic blood pressure.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 18 (1980), S. 231-235 
    ISSN: 1432-1041
    Keywords: molsidomine ; hypertension ; hypotension ; angina pectoris
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Molsidomine (M), a new long-lasting antianginal compound, was studied in 38 hypertensive patients to assess its antihypertensive properties. Six patients were selected for an acute, single dose comparative trial with placebo over 8 h after treatment. The remaining 32 patients were used in a 1 month trial to study the effect on BP of more prolonged treatment. Systolic, diastolic and mean BP were significantly reduced after a single dose of M 4 mg, and the effect lasted for about 8 h. M also inhibited the hypertensive response to isometric exercise in handgrip tests performed 1 and 8 h after M ingestion. A dose-related decrease in systolic and diastolic BP in the one month trial was also observed. In addition to its antianginal properties, M appears to possess an interesting effect on BP in mildly to moderately hypertensive patients. A fall in BP is also a valuable effect in coronary patients with augmented metabolic demands of the heart.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1041
    Keywords: Molsidomine ; penbutolol ; angina pectoris ; angina severity scores ; ergometric tests ; betablocking agents ; pre-load reduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In order to test the additional efficacy of the combination of a beta blocker (penbutolol 40 mg single dose) with molsidomine (2 mg single dose), a double blind cross-over trial was performed in 30 patients with stable angina pectoris. Stress tests were done before and 1 h after the beta blocker alone and the combination therapy. Some training effect could be detected on comparing results from the first and second days. Combined therapy showed a better response of resting systolic arterial pressure, resting and maximal diastolic pressure, heart rate gain (from rest to maximal effort) and particularly in the angina severity score. All of these variables changed significantly in comparison to the beta blocker alone, 46 out of 60 post-drug ergometric studies were negative; of the 14 positive tests, 11 followed the beta blocker and only 3 the combined therapy. The combination of a preload reducer molsidomine and a beta blocker may be adequate for patients only partially compensated or with cardiomegaly and/or a depressed ejection fraction.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Journal of metastable and nanocrystalline materials Vol. 24-25 (Sept. 2005), p. 253-256 
    ISSN: 1422-6375
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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