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  • 1
    Electronic Resource
    Electronic Resource
    The effect of intrauterine growth retardation on the development of renal nephrons (1992)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 99 (1992), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To investigate the effect of Type II (asymmetrical) intrauterine growth retardation (IUGR) on renal development.Design A prospective descriptive study.Setting Department of Fetal and Infant Pathology, Liverpool Children's Hospital.Subjects Six (severely) affected IUGR stillbirths of known gestational age with a control group of stillbirths with birthweight 〉 10th centile, and eight liveborn IUGR infants who died within a year of birth with a control group of appropriately grown infants who died within a year of birth (postnatal groups).Techniques The kidneys from all the groups studied were analysed using unbiased, reproducible and objective design-based stereological techniques.Main outcome measures Total renal nephron (glomerular) numbers and average volumes of total nephron and cortical and medullary nephron segments.Results Nephron number estimates lay below the control group's 5% prediction limit in five out of the six growth-retarded stillbirths, and were significantly (P〈0.005, IUGR at 65% of the control mean) reduced in the postnatal group. Estimates of nephron (segment) volume did not differ between control and IUGR groups.Conclusions Type II intrauterine growth retardation may exert a profound effect on renal development. The reduced nephron number at birth, together with the lack of any early postnatal compensation in either nephron number or nephron size, emphasizes the need for vigorous antenatal surveillance for IUGR and consideration of elective preterm delivery of affected fetuses. A systematic review of other organs, which develop in a similarly rapid fashion during the late intrauterine period, is indicated by this work. With one exception, all birthweights in the growth-retarded groups were below the third centile, thus the precise quantitative relation between progressive IUGR and renal function requires further assessment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1992.tb13726.x
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  • 2
    Electronic Resource
    Electronic Resource
    A Liquid Viscosity-Temperature-Chemical Constitution Relation for Organic Compounds (1972)
    s.l. : American Chemical Society
    Industrial and engineering chemistry 11 (1972), S. 20-25 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/i160041a004
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  • 3
    Electronic Resource
    Electronic Resource
    Corticosteroids and childhood asthma (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 21 (1991), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1991.tb00868.x
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  • 4
    Electronic Resource
    Electronic Resource
    Electron microscopy in the diagnosis of microbiological disease
    Amsterdam : Elsevier
    Ultramicroscopy 19 (1986), S. 114 
    Details
    ISSN: 0304-3991
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Electrical Engineering, Measurement and Control Technology , Natural Sciences in General , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0304-3991(86)90082-3
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  • 5
    Electronic Resource
    Electronic Resource
    Scalp cyst with heterotopic brain tissue (1993)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 129 (1993), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary A multilocular scalp lesion was noticed at birth in a female infant. There was no unnderlying skull defect. Histological examination revealed neural tissue staining with S-l00 and GFAP, but not with a neurofilament stain, which is in keeping with a glial cell origin. Heterotopic brain tissue is a rare developmental abnormality. which is usually has no effect on neurological development. It should be considered in the differential diagnosis of scalp lesions in neonates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1993.tb03525.x
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  • 6
    Electronic Resource
    Electronic Resource
    Ploidy analysis on Wilms' tumour touch imprints using ethidium bromide and automated image analysis integrated confocal laser scanning microscopy (1995)
    Springer
    Virchows Archiv 427 (1995), S. 101-104 
    Details
    ISSN: 1432-2307
    Keywords: Wilms' Tumour ; Ethidium Bromide ; Ploidy ; Image Analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although image analysis (IA) is increasingly being used to quantitate nuclear DNA, comparative data between fluorescence methods of IA and flow cytometry (FCM) is limited. In this study fluorescence IA was compared with FCM data in a series of Wilms' tumour touch preparations. Airdried touch imprints that had previously been Giemsa stained were restained with ethidium bromide. Confocal fluorescence images were obtained with a confocal laser scanning microscope and assessed by a fully automated IA package. Data was collected from 400 nuclei per imprint. The resulting DNA histograms were analysed and ploidy status and DNA indices determined using standard criteria. Results were compared with those derived from FCM analysis of nuclear suspensions. Ten of twelve tumours were concordant by both techniques. However in two cases assessed as diploid by FCM, IA identified aneuploidy. Excellent correlation between DNA indices as assessed by both techniques was observed (r=0.987). In the three cases for which both unstained and Giemsa stained touch imprints were available for IA, the histogram configurations did not differ significantly. Fluorescence IA is an accurate and sensitive technique for DNA quantitation, which appears at least comparable to FCM assessment and which has a number of important advantages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00203744
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  • 7
    Electronic Resource
    Electronic Resource
    PCNA independence of Ki-67 expression in HPV infection.
    Amsterdam : Elsevier
    Cell Biology International 17 (1993), S. 1001-1004 
    Details
    ISSN: 1065-6995
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1006/cbir.1993.1029
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  • 8
    Electronic Resource
    Electronic Resource
    PCNA Ki-67 dissociation in childhood acute lymphoblastic leukaemia. An Immunofluorescent Laser Confocal Scanning Microscopical study.
    Amsterdam : Elsevier
    Cell Biology International 18 (1994), S. 869-874 
    Details
    ISSN: 1065-6995
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1006/cbir.1994.1123
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  • 9
    Electronic Resource
    Electronic Resource
    HBr electrolysis in the Ispara Mark 13A flue gas desulphurization process: electrolysis in a DEM cell (1990)
    Springer
    Journal of applied electrochemistry 20 (1990), S. 60-68 
    Details
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract The potential application of a DEM cell for the electrolysis of hydrogen bromide in the Ispra Mark 13A process for flue gas desulphurization has been tested in a number of laboratory experiments and in long-duration tests in a bench-scale plant of the process. Satisfactory electrode materials have been found, i.e. Hastelloy C 276 for the cathode and a RuO2 coating on titanium for the anode. Both electrode materials showed a good stability during a 1500 hours experiment. Cell voltage/current density relationships have been determined during bench-scale plant operation. A typical value is 1.5V at a current density of 2.5 kA m−2. It has been shown that in an undivided cell a cathodic back reaction occurs which causes a decrease of the current efficiency. Under normal operation conditions current efficiencies of about 90% are obtained. A simplified flow model for the DEM cell was developed which is useful in understanding the phenomena which occur during scale-up of the cell. An industrial size installation for the production of 170 kg h−1 of bromine at a current density of 2 kA m−2 was constructed and has been in operation since August 1989.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01012472
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  • 10
    Electronic Resource
    Electronic Resource
    A quantitative immunocytochemical analysis of total surface area of blood-brain barrier in developing rat brain (1996)
    Springer
    Comparative clinical pathology 6 (1996), S. 214-220 
    Details
    ISSN: 1433-2981
    Keywords: Rat ; Blood-brain barrier ; Development ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A mouse monoclonal antibody which specifically reacts with putative blood-brain barrier (BBB) competent endothelial cells of rat cerebral capillaries was used to identify barrier competent cells in the central nervous system (CNS). The development of the cerebral capillaries and the BBB was examined and quantified, from day 6 to day 40 postpartum, using immunocytochemical and unbiased stereological techniques. There was a progressive increase in capillary formation postnatally, with collateral branching observed with progressive age. BBB development was confined to individual endothelial cells located at the periphery of the cortex until day 10 postpartum. Antibody binding progressively increased postnatally, contributing 30% of the total capillary surface area by day 20. There was a rapid elevation of reactivity from day 20 to day 40, with a mean of 83% by day 40. The BBB constitutes minimal amounts of brain vascular capillaries before day 10 of life in the rat. There is a slower increase in BBB than in total capillaries between days 10 and 20. There is a reversal of this trend between days 20 and 40.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00378113
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