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Reversal of scopolamine-induced amnesia by phosphatidylserine in rats (1986)

Zanotti, Adriano ; Valzelli, Luigi ; Toffano, Gino

Springer

Psychopharmacology 90 (1986), S. 274-275

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ISSN: 1432-2072

Keywords: Amnesia ; Phosphatidylserine ; Scopolamine ; Propranolol ; Rat

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Scopolamine (2 mg/kg IP) and propranolol (55 mg/kg IP), given before a single learning trial, reduce retention of a passive avoidance response in rats. Phosphatidylserine, 30–60 mg/kg IP, antagonizes the amnesic effect of scopolamine but not that of propranolol. The retention of the passive avoidance response is not affected by phosphatidylserine given alone. The results indicate that this phospholipid selectively counteracts the action of scopolamine on passive avoidance acquisition, probably via a cholinergic mechanism.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00181257

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