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  • 1
    Electronic Resource
    Electronic Resource
    A unique biomedical resource at risk (2005)
    [s.l.] : Nature Publishing Group
    Nature 437 (2005), S. 30-32 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] As the closest living relative of humans, the chimpanzee holds a unique place in biomedical research. Several major medical advances have been possible only through research with chimpanzees. The completion of the draft sequence of the chimpanzee genome, the first non-human primate genome to be ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/437030a
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  • 2
    Electronic Resource
    Electronic Resource
    H-2 haplotypes, genes, regions, and antigens: First listing (1978)
    Springer
    Immunogenetics 6 (1978), S. 489-512 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01563941
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  • 3
    Electronic Resource
    Electronic Resource
    Structure and evolution of opossum, guinea pig, and porcupine cytochrome b genes (1993)
    Springer
    Journal of molecular evolution 36 (1993), S. 327-334 
    Details
    ISSN: 1432-1432
    Keywords: Cytochrome b ; Mitochondrial DNA ; Mammalian phylogeny ; Functional constraints ; Coevolution ; Cavia porcellus ; Monodelphis domestica ; Hystrix africaeaustralis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We have sequenced the mitochondrial cytochrome b gene from the guinea pig, the African porcupine, and a South American opossum. A phylogenetic analysis, which includes 22 eutherian and four other vertebrate cytochrome b sequences, indicates that the guinea pig and the porcupine constitute a natural clade (Hystricomorpha) that is not a sister group to the clade of mice and rats (Myomorpha). Therefore, the hypothesis that the Rodentia is paraphyletic receives additional support. The artiodactyls, the perissodactyls, and the cetaceans form a group that is separated from the primates and the rodents. The 26 sequences are used to study the structure/function relationships in cytochrome b, whose function is electron transport. Most of the amino acid residues involved in the two reaction centers are well conserved in evolution. The four histidines that are believed to ligate the two hemes are invariant among the 26 sequences, but their nearby residues are not well conserved in evolution. The eight transmembrane domains represent some of the most divergent regions in the cytochrome b sequence. The rate of nonsynonymous substitution is considerably faster in the human and elephant lineages than in other eutherian lineages; the faster rate might be due to coevolution between cytochrome b and cytochrome c.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00182180
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  • 4
    Electronic Resource
    Electronic Resource
    Announcement (1985)
    Springer
    Human genetics 〈Berlin〉 70 (1985), S. 290-290 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273463
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  • 5
    Electronic Resource
    Electronic Resource
    Strong teratocarcinoma transplantation loci, Gt-1 and Gt-2, Flank H-2 (1981)
    Springer
    Immunogenetics 13 (1981), S. 413-419 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Evidence is presented for the existence of two strong murine teratocarcinoma transplantation antigens (Gt) on the cell line PCC3. It is shown that the loci governing expression of these antigens are linked to the H-2 complex. These loci have been further mapped with respect to the brachyury marker (T) and H-2: Gt-1 lies 5±2 crossover units proximal to H-2 and 12±2 crossover units distal to T, Gt-2 lies 21±4 crossover units distal to H-2. It is possible that these strong transplantation antigens provide an embryonic analogue to the adult major histocompatibility system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00346022
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  • 6
    Electronic Resource
    Electronic Resource
    X-linked gene expression in metatherian fibroblasts: Evidence from theGpd andPgk-A loci of the Virginia opossum and the red-necked wallaby (1989)
    Springer
    Biochemical genetics 27 (1989), S. 313-320 
    Details
    ISSN: 1573-4927
    Keywords: X-chromosome inactivation ; marsupials ; cultured fibroblasts ; glucose-6-phosphate dehydrogenase ; phosphoglycerate kinase-A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Fibroblasts cultured from ear pinna biopsies of Virginia opossums (Didelphis virginiana) and red-necked wallabies (Macropus rufogriseus) were examined electrophoretically to determine the relative expression levels of the maternally and paternally derived alleles at X-linked, enzyme-coding loci. Only the maternally derived allele was expressed at thePgk-A locus in fibroblasts of heterozygousD. virginiana (M. rufogriseus not examined), but fibroblasts of both species exhibited evidence of paternal allele expression a t theGpd locus. Furthermore, the heterozygous G6PD phenotypes in both species were skewed in favor of the maternal gene product, as expected if the paternal allele is only partially (incompletely) expressed. ForM. rufogriseus this result is contrary to a previous finding which suggested equal expression of bothGpd alleles in cultured fibroblasts of this species. The present results suggest that X-linked genes in metatherian fibroblasts are subject to the same kind of determinate, paternal allele inactivation, incomplete at some loci, described previously for X-linked genes in adult tissues and that the pattern of paternal X-linked gene expression in these cells is independent of the patterns in the tissues from which the fibroblasts are derived.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00554166
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  • 7
    Electronic Resource
    Electronic Resource
    Biochemical genetic markers of squirrel monkeys and their use for pedigree validation (1990)
    Springer
    Biochemical genetics 28 (1990), S. 41-56 
    Details
    ISSN: 1573-4927
    Keywords: isozymes ; polymorphisms ; paternity ; maternity ; pedigree ; Saimiri
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Family data for 14 biochemical genetic markers of squirrel monkeys (genusSaimiri) were derived from 73 pedigreed progeny and both parents of each, as well as from 16 additional progeny and one parent of each. The data for each marker and the phenotypic patterns were consistent with autosomal codominant inheritance. It was concluded from the genetic marker data that the pedigree records of seven progeny were incorrect. Retrospective investigations of colony records followed by typing of animals that might possibly have been a parent enabled five of the pedigree records to be corrected. Although five of the pedigree errors were cases of mistaken paternity, the other two apparently were the consequence of infant swapping between dams shortly after birth. Because squirrel monkeys exhibit a high degree of allomaternal behavior, infant swapping between dams may occur more frequently than in many other nonhuman primate species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00554820
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  • 8
    Electronic Resource
    Electronic Resource
    Biochemical characteristics and subcellular localizations of rat liver neuraminidase isozymes: A paradox resolved (1990)
    Springer
    Biochemical genetics 28 (1990), S. 283-298 
    Details
    ISSN: 1573-4927
    Keywords: neuraminidase isozymes ; fluorometric assay ; enzyme destabilization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A striking discrepancy in the abilities of two analytical approaches (fluorometric and electrophoretic) to detect the effect of a gene,Neu-2, on rat liver neuraminidase phenotypes led us to examine the biochemical and physical properties of the liver isozymes NEU-1 and NEU-2 that might be responsible for this difference. Cell fractionation via Percoll gradient centrifugation revealed NEU-1 activity almost exclusively in the lysosomal cell fraction, while NEU-2 was strictly cytosolic in distribution. The two isozymes were also found to differ inpH activity curves and optima (optima: 4.6–4.8 and 5.4–5.8 for NEU-1 and NEU-2, respectively) and in solubility characteristics (NEU-2 highly soluble; NEU-1 relatively insoluble but solubilized by freezing/thawing). Both isozymes were found to be freeze-thaw stable in crude, whole-cell extracts, but NEU-1 was destabilized in the enriched (partially purified) lysosomal subcellular fraction. Consideration of these properties relative to those described previously for unidentified cytosolic and membrane bound (lysosomal) rat liver neuraminidases (Tulsiani, D. R. P., and Carubelli, R.,J. Biol. Chem. 245:1821, 1970) leads us to believe that NEU-2 also is destabilized by partial purification and that NEU-1 and NEU-2 have very different relative abundances within the cell. The biochemical and physical differences between NEU-1 and NEU-2 can account for the discrepant abilities of the fluorometric and electrophoretic approaches to detect the effects ofNeu-2. Ways to increase the sensitivity of the fluorometric approach for quantitative assays of specific NEU-1 and NEU-2 activity are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02401418
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  • 9
    Electronic Resource
    Electronic Resource
    Biochemical characteristics and subcellular localizations of rat liver neuraminidase isozymes: A paradox resolved (1990)
    Springer
    Biochemical genetics 28 (1990), S. 283-298 
    Details
    ISSN: 1573-4927
    Keywords: neuraminidase isozymes ; fluorometric assay ; enzyme destabilization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A striking discrepancy in the abilities of two analytical approaches (fluorometric and electrophoretic) to detect the effect of a gene,Neu-2, on rat liver neuraminidase phenotypes led us to examine the biochemical and physical properties of the liver isozymes NEU-1 and NEU-2 that might be responsible for this difference. Cell fractionation via Percoll gradient centrifugation revealed NEU-1 activity almost exclusively in the lysosomal cell fraction, while NEU-2 was strictly cytosolic in distribution. The two isozymes were also found to differ inpH activity curves and optima (optima: 4.6–4.8 and 5.4–5.8 for NEU-1 and NEU-2, respectively) and in solubility characteristics (NEU-2 highly soluble; NEU-1 relatively insoluble but solubilized by freezing/thawing). Both isozymes were found to be freeze-thaw stable in crude, whole-cell extracts, but NEU-1 was destabilized in the enriched (partially purified) lysosomal subcellular fraction. Consideration of these properties relative to those described previously for unidentified cytosolic and membrane bound (lysosomal) rat liver neuraminidases (Tulsiani, D. R. P., and Carubelli, R.,J. Biol. Chem. 245:1821, 1970) leads us to believe that NEU-2 also is destabilized by partial purification and that NEU-1 and NEU-2 have very different relative abundances within the cell. The biochemical and physical differences between NEU-1 and NEU-2 can account for the discrepant abilities of the fluorometric and electrophoretic approaches to detect the effects ofNeu-2. Ways to increase the sensitivity of the fluorometric approach for quantitative assays of specific NEU-1 and NEU-2 activity are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00554085
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  • 10
    Electronic Resource
    Electronic Resource
    Plasma protease inhibitor (PI) system in the laboratory opossum,Monodelphis domestica (1996)
    Springer
    Biochemical genetics 34 (1996), S. 389-399 
    Details
    ISSN: 1573-4927
    Keywords: protease inhibitor ; polymorphism ; genetics ; Monodelphis domestica
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Protease inhibitor (PI) polymorphism was observed in the laboratory opossum,Monodelphis domestica, by either one-dimensional acid polyacrylamide gel electrophoresis (PAGE; pH 4.6) or isoelectric focusing (pH 3.5-5.0) followed by immunoblotting with rabbit antiserum to human α1-antitrypsin; but acid PAGE produced superior resolution of the PI proteins. Family studies demonstrated an inheritance of nine codominant autosomal alleles,PI D ,PI E ,PI F ,PI G ,PI H ,PI I ,PI J ,PI K , andPI M , and a population study revealed frequencies of 0.411, 0.010, 0.341, 0.034, 0.023, 0.071, 0.035, 0.020, and 0.055, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00554414
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