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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 1 (1962), S. 397-405 
    ISSN: 1432-0533
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Inoculation of polyoma virus into newborn rats can produce, a diffuse neoplastic process of the leptomeninges, which is comparable to the human primary leptomeningeal sarcomatosis and to the intracranial sarcomas produced by Rous virus in chickens and by polyoma virus in Syrian hamsters. The neuropathological features of these lesions are described. The same results were obtained by intravenous intracerebral or subcutaneous inoculation as well. The hydrocephalus can be explained by the proliferation of the tumour cells in the subarachnoïdal space. The authors point out that some hemorrhagic lesions result from the strangulation of blood vessels by neoplastic cuffs.
    Notes: Résumé L'inoculation du virus polyome chez le raton peut provoquer la formation d'un processus néoplasique diffus des leptoméninges, qui est comparable à la sarcomatose méningée primitive décrite chez l'homme et aux sarcomes intra-crâniens provoqués chez le poulet par le virus de rous et chez le hamster par le virus polyome. Les auteurs décrivent les aspects neuropathologiques de ces lésions et montrent qu'elles peuvent s'obtenir aussi bien par l'inoculation intra-veineuse, intra-cérébrale ou sous-cutanée du virus. Ils expliquent l'apparition de l'hydrocéphalie par l'invasion tumorale des espaces sous-arachnoïdiens. Ils montrent également que certaines lésions hémorragiques proviennent de la strangulation vasculaire par des manchons tumoraux.
    Type of Medium: Electronic Resource
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