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Close linkage of retinoic acid receptor genes with homeobox- and keratin-encoding genes on paralogous segments of mouse Chromosomes 11 and 15 (1992)

Nadeau, Joseph H. ; Compton, John G. ; Giguère, Vincent ; [et al.]

Springer

Mammalian genome 3 (1992), S. 202-208

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ISSN: 1432-1777

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract Retinoic acid is essential for normal development and growth of structures such as head and limbs, and it can act as morphogen or teratogen. Retinoic acid induces expression of genes such as the homeobox genes and keratin type I and type II genes. Retinoic acid receptors are nuclear transcription factors that play a key role in retinoid physiology. As part of the characterization of retinoic acid receptor gene family, linkage of genes encoding the three receptors was determined by using interspecific backcross and recombinant inbred strain analysis of restriction fragment variants. Retinoic acid receptor α is located on mouse Chromosome (Chr) 11 near the homeobox-2 complex and the keratin type I gene complex, whereas retinoic acid receptor γ is on mouse Chr 15 near the homeobox-3 complex and the keratin type II complex. Close genetic proximity of these functionally related genes may be significant. We confirmed assignment of retinoic acid receptor β to the centromeric portion of Chr 14. These linkage assignments provide further evidence for duplicated segments in the mouse genome.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00355720

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Identification of genes showing altered expression in preimplantation and early postimplantation parthenogenetic embryos (1995)

Mann, Mellissa ; Latham, Keith E. ; Varmuza, Sue

Chichester [u.a.] : Wiley-Blackwell

Developmental Genetics 17 (1995), S. 223-232

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ISSN: 0192-253X

Keywords: Genomic imprinting ; parthenogenetic embryos ; biallelic expression ; Life and Medical Sciences ; Genetics

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology

Notes: Uniparental embryos have been instrumental in studying imprinting because contributions from the parental genomes can be determined unambiguously. In this study, we set out to identify imprinted genes showing differential expression between parthenogenetic and fertilized embryos during preimplantation and early postimplantation stages of development. We identified three genes-apolipoprotein E, pyruvate kinase-3, and protein phosphatase 1 gamma-that represent excellent candidates for imprinted genes, based on the results of the differential screen, their function in differentiation and the cell cycle, and their location within imprinted chromosomal regions. In addition, two novel genes expressed in trophoblast were identified, 1661 and RA81. These genes, together with four known imprinted genes, H19, Igf2r, Igf2, and Snrpn, showed evidence of expression from both parental alleles in early stage embryos, indicating a role for postfertilization processes in regulating imprinted gene function. © 1995 Wiley-Liss, Inc.

Additional Material: 4 Ill.