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Single-dose and steady-state pharmacokinetics of sabeluzole in senile dementia of Alzheimer type patients (1992)

Deyn, P. P. ; Velde, V. ; Verslegers, W. ; [et al.]

Springer

European journal of clinical pharmacology 43 (1992), S. 661-662

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ISSN: 1432-1041

Keywords: Sabeluzole, Alzheimer ; pharmacokinetics, single and repeated dosing, (senile) dementia, tolerability

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The single- and repeated-dose pharmacokinetics of sabeluzole have been determined in six elderly patients with [senile] dementia of the Alzheimer type. After a single oral dose of 10 mg sabeluzole, the peak plasma concentration was attained at 1 to 4 h; it averaged 42 ng·ml−1. On repeated dosing (10 mg b. d.), steady-state was virtually attained after 3 days of treatment. Steadystate mean trough and peak plasma concentrations fluctuated between 53 and 94 ng·ml−1. The mean terminal half-life after a single dose and at steady-state was of the order of 33 h. Sabeluzole was well tolerated and at the end of treatment, no systematic changes in blood haematology, biochemistry or urinalysis were seen.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02284969

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Itraconazole penetrates the nail via the nail matrix and the nail bed—an investigation in onychomycosis (1991)

MATTHIEU, L. ; DONCKER, P. ; CAUWENBERGH, G. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Clinical and experimental dermatology 16 (1991), S. 0

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ISSN: 1365-2230

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Nail-matrix kinetics were studied in 21 patients (19 with onychomycosis, two with tinea corporis) as soon as taking itraconazole (Sporanox®) 100 mg daily for up to 7 months. Itraconazole was detected in the distal nail as soon as 1 month after the start of therapy (42 ng/g in fingernails and 16 ng/g in toenails). During the course of treatment, this concentration rose and reached a mean of 160 ng/g in fingernail clippings and 197 ng/g in toenail clippings. Moreover, in fingernails of 12 out of 21 patients and in toenails of six out of 20 patients, itraconazole was detected in the distal nail clippings before full outgrowth of the fastest-growing nail. In most patients, itraconazole was detected in the distal nail clippings earlier than would be expected if the drug were incorporated only via the nail matrix, indicating that in addition to the nail matrix, a second route of penetration into the nail exists, i.e. the nail bed.