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  • 1
    Electronic Resource
    Electronic Resource
    The secular trend of height and menarche in Belgium: are there any signs of a future stop? (1985)
    Springer
    European journal of pediatrics 144 (1985), S. 306-309 
    Details
    ISSN: 1432-1076
    Keywords: Secular trend ; Height and weight ; Menarche (age at) ; Brussels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Changes such as an increase in stature, in weight and an earlier physical and sexual maturation have been observed since the 19th century in Belgium as in most industrialized countries. In this paper, we consider the secular trend in height, weight and puberty (especially menarche) over the last 20 years in Brussels. During the period 1980–1982, 4177 subjects, from the Belgian population of Brussels, aged 3–26 years, have been measured and compared with Belgian subjects living in Brussels in 1960. In our sample, we observe a statistically significant increase in height (and weight), but this trend is less rapid than the increases noticed before in Belgium. Status quo data on menarche from 1048 girls from this sample were analysed by centiles and the probit method. For the first time in Belgium, it seems that the median age is stabilized at 13.0 years. However, the number of late menarches is still evolving.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441769
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Alfentanil kinetics in renal insufficiency (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 245-247 
    Details
    ISSN: 1432-1041
    Keywords: alfentanil ; uraemia ; i.v. administration ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Alfentanil 100 µg/kg was administered as an i.v. bolus to 9 patients with severe chronic renal dysfunction (creatinine clearance 1.0±1.2 ml/min) requiring regular haemodialysis. Plasma alfentanil concentrations were measured by a specific radioimmunoassay. Individual plasma concentration-time curves were fitted to a two-compartment open model. Mean distribution and elimination half-lives were 3.7 min and 58 min, respectively. The apparent volumes of distribution of the central compartment and the total volume of distribution at steady-state were 91 ml/kg and 304 ml/kg, respectively. Alfentanil plasma clearance was 5.3±2.5 ml/min/kg. All the patients tolerated alfentanil well and no side-effects nor delayed recovery were observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614313
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Combined continuous spinal-epidural anaesthesia with a single interspace, double-catheter technique (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 48 (1993), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A double catheter, single interspace combined spinal-epidural anaesthetic was performed in 12 ASA grade 3 patients. The technique failed in one patient in whom the intrathecal catheter could not be inserted satisfactorily. In another patient, the epidural catheter was accidentally placed intrathecally. The maximum height of the block obtained with hyperbaric lignocaine or bupivacaine was below T10 in all patients and there were no adverse cardiovascular changes. As opposed to a classical combined spinal-epidural block, this technique is most suitable for very debilitated patients. The advantages are the ability to titrate the intrathecal dose of the local anaesthetic to achieve the desired dermatomal level and to test the correct position of the epidural catheter before injecting drugs intrathecally.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1993.tb07484.x
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  • 4
    Electronic Resource
    Electronic Resource
    Respiratory arrest after sufentanil (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 43 (1988), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1988.tb05452.x
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  • 5
    Electronic Resource
    Electronic Resource
    Intranasal sufentanil for pre-operative sedation (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 43 (1988), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sufentanil, a short-acting and potent narcotic agent, was studied as a premedicant administered by the nasal route. A total dose of 5 μg appeared to be too low, while either 10 or 20 μg was very effective in producing sedation. Side effects were minor. There appeared to be no differences between nose drops and spray. In a further study, sufentanil nose drops were compared with saline (0.9% in a double-blind fashion. Sedation of rapid onset but of limited duration was observed in the majority of patients who received sufentanil.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1988.tb08970.x
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  • 6
    Electronic Resource
    Electronic Resource
    Comparison of epidural sufentanil plus clonidine with sufentanil alone for postoperative pain relief (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 45 (1990), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sufentanil 25 μg plus clonidine 1 μg/kg administered epidurally was compared with epidural sufentanil 50 μg alone in a double-blind fashion for pain relief in 40 patients after abdominal surgery. The duration of complete pain relief was significantly longer in those who received the mixture. Oxygen saturation was reduced 10 and 20 minutes after sufentanil alone, but remained stable after sufentanil and clonidine. There were significant decreases in arterial blood pressure in the latter group that were maximum between 20 and 120 minutes after administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1990.tb14824.x
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  • 7
    Electronic Resource
    Electronic Resource
    Postoperative intrathecal patient-controlled analgesia with bupivacaine, sufentanil or a mixture of both (1998)
    Oxford : Blackwell Science Ltd
    Anaesthesia 53 (1998), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In a randomised double-blind study, 45 patients, scheduled for major orthopaedic surgery under continuous spinal anaesthesia, received for relief of postoperative pain patient-controlled analgesia with either sufentanil 2 μgml−1, bupivacaine 0.0625% or a mixture of both by the intrathecal route. The mean (SD) consumption of sufentanil and bupivacaine during the first 12 h was 65.5 (27.1) μg and 18.2 (4.8) mg, respectively. Combining bupivacaine and sufentanil reduced the consumption of both to ≈40% as compared to the administration of each component separately. Pain relief was very good in all subjects, although this was obtained faster with the combined regimen. Moreover, more patients in this group remained completely painfree during the entire observation period (p 〈 0.05). The incidence of hypotension was low and not significantly different when the plain bupivacaine group was compared with the two other groups. Nausea and vomiting were significantly more frequently observed in both groups treated with sufentanil. Motor block was not a major problem and was noticed during the first 2 h of treatment only. Tachyphylaxis did not occur. It was concluded that the groups receiving plain bupivacaine and sufentanil alone experienced pain relief of good quality. The use of a mixture, however, accelerated the onset of analgesia, improved the analgesic quality and reduced the doses for both components by 60% but at the expense of a higher incidence of nausea and vomiting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.1998.00517.x
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  • 8
    Electronic Resource
    Electronic Resource
    A new combined spinal–epidural apparatus: measurement of the distance to the epidural and subarachnoid spaces (1997)
    Oxford BSL : Blackwell Science Ltd
    Anaesthesia 52 (1997), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A new combined spinal–epidural anaesthesia apparatus with a 27G lockable spinal needle was used in 151 patients. Two groups could be created, based on whether dural perforation was felt or not (group 1: with dural click; group 2: no dural click). Measurements of the epidural space depth and of the protrusion of the spinal needle from the epidural needle (tip-to-tip distance) were made. The mean depth of the epidural space was 5.59 cm. Correlations were found with body weight, weight-to-height ratio and body mass index (p 〈 0.001). The mean tip-to-tip distance measured was 7.0 mm in the patients of group 1, whereas in group 2 a distance of 8.9 mm was found. This difference was statistically significant. Correlations were found between the epidural space width and the patient's height, weight-to-height ratio and body mass index. Four patients felt paraesthesia during placement of the spinal needle and, in another four patients, aspiration was necessary to detect cerebrospinal fluid. Two patients needed epidural top-ups due to insufficient level of anaesthesia. The lockable spinal needle provides safe and stable conditions during injection and a high rate of success in reaching the subarachnoid space.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1997.93-az0093.x
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  • 9
    Electronic Resource
    Electronic Resource
    Patient-controlled epidural analgesia with sufentanil following Caesarean section: the effect of adrenaline and clonidine admixture (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 49 (1994), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sixty patients, scheduled for Caesarean section were randomly allocated to receive by the epidural route in a double-blind fashion one of the following patient-controlled analgesia mixtures for the relief of postoperative pain: sufentanil 2 μg.ml-1 in 0.9% sodium chloride, sufentanil 2 μg.ml-1+ adrenaline 2.5 μg.ml-1, or sufentanil 2 μg.ml-1+ clonidine 3 μg.ml-1. Patient-controlled analgesia settings were a basal infusion rate of 2.5 ml.h-1, an incremental dose of 2.5 ml, a lockout interval of 10 min and a 1-h limit of 10 ml. Whereas patient demographics and pain scores between the groups were not different, the 24-h consumption of sufentanil was significantly lower in the groups receiving a combination (167.5 SD 45 and 139.1 SD 31.9 μg for the adrenaline and clonidine groups respectively) as compared to the plain sufentanil regimen (208.2 SD 38.9 μg). Although sufentanil requirements were the lowest in the clonidine admixture group, there were no differences with regard to sedation as compared to the plain sufentanil group. The quality of sleep appeared to be significantly better in the sufentanil/adrenaline group despite a significantly lower degree of sedation and higher incidence of pruritus. Treatment of pruritus with naloxone did not seem to influence the quality of analgesia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1994.tb04447.x
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  • 10
    Electronic Resource
    Electronic Resource
    The influence of labetalol on arterial blood gas data, pulmonary haemodynamics and pulmonary shunting (1988)
    Springer
    Intensive care medicine 15 (1988), S. 42-45 
    Details
    ISSN: 1432-1238
    Keywords: Labetalol ; Head injury ; Blood gas data ; Haemodynamics ; Systemic, pulmonary ; Pulmonary ; Shunting, mechanics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The arterial oxygen and carbon dioxide tensions, pulmonary and systemic haemodynamics and pulmonary shunting and mechanics were measured during the first 30 min after intravenous labetalol administration. Thirty patients, recovering in the intensive care unit after neurosurgical interventions were randomly divided in 2 groups of 15 patients, receiving either labetalol or placebo. In the labetalol treated group the arterial oxygen tension decreased from 553.6±16.8 to 529.3±19.8 mmHg 5 min after the injection of labetalol. A concomitant increase in arterial carbon dioxide tension from 40.1±1.1 to 45.5±1.3 mmHg was noticed. Pulmonary vascular resistance decreased from 159.6±14.7 to 116.7±11.7 dynes·sec·cm-5 and pulmonary shunting increased from 4.8%±1.4% to 8.1%±2.4% 5 min following injection. All these changes were statistically significant for p〈0.01. After 30 min all values had returned to their initial level. No changes were registered in the control group. As airway resistance appeared not to be affected by the labetalol administration it may be concluded that the observed changes in blood gas data are most likely due to a transient decrease of the pulmonary vascular resistance with a concomitant increase in pulmonary shunting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00255635
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    Paper (German National Licenses)
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