ISSN:
1471-0528
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
Measurements of blood coagulability and liver function parameters were made on alternate weeks in 14 young unmarried female volunteers for two months before and for three months during fortnightly intramuscular injections of 100 mg. of dydrogesterone (Duphaston Depot). No difference, significant at the 5 per cent level, was found for the following: fibrinogen, the prothrombin-proconvertin complex, factor VII, factor X, partial thromboplastin time with or without previous kaolin activation, euglobulin lytic activity, antiplasmin, platelet count, collagen induced platelet aggregation or platelet adhesiveness to a glass bead column. A small but statistically significant reduction of factor VIII and plasminogen was noted in association with dydrogesterone administration. No significant difference of serum glutamic pyruvic or serum glutamic oxalacetic transaminases levels or of thymol and zinc sulphate turbidity tests was observed between the samples taken before and during dydrogesterone administration. A slight but statistically significant reduction of alkaline phosphatase and of total bilirubin was, however, noted.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1471-0528.1973.tb02136.x
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