ISSN:
1432-1106
Keywords:
ATD
;
Steroid binding sites
;
LH release
;
Hypothalamus
;
Brain sections
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Prevention of testosterone aromatization in the female rat pups by perinatal treatment with 1,4,6 androstatriene-3,17-dione (ATD) induces an important defeminization as shown by a reduction of fluctuations of LH release after castration and estradiol implantation. The fact that, under our in vitro experimental conditions, ATD is able to displace testosterone binding in the hypothalamus whereas estradiol does not, confirms the hypothesis that ATD acts on aromatase. The most attractive explanation for the defeminization effect of ATD is then an estrogen-like action of ATD.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00340477
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