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  • 1
    Electronic Resource
    Electronic Resource
    Effect of Snake Venom and Endotoxin on Cortical Electrical Activity (1964)
    [s.l.] : Nature Publishing Group
    Nature 203 (1964), S. 1387-1388 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Thirty adult mongrel dogs and fifteen monkeys of the Cynapthecoid group (sooty mangabey) were used. All animals were anaesthetized with pentobarbital sodium (30 mg/kg). Arterial blood pressure was continuously recorded using a Statham strain gauge and an E and M six-channel physiograph. The ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2031387b0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of treatment with whole bee venom on cage activity and plasma cortisol levels in the arthritic dog (1976)
    Springer
    Inflammation 1 (1976), S. 167-174 
    Details
    ISSN: 1573-2576
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A series of 24 mixed-breed dogs were used to study the physiological effects of whole bee venom on canine arthritic-like conditions. 16 were randomly selected normal dogs and 8 were suspect arthritic animals confirmed by X-ray examination and special physical examination. The control dogs were divided into groups I and II and the arthritic groups III and IV. Groups I and III received injections of sterile saline while groups II and IV were given 1 mg whole bee venom subcutaneously on days 30, 37, 50, and 60. Plasma cortisol levels were measured weekly and cage activity recorded daily using a K and R Pedometer. Following bee venom injection plasma cortisol levels increased in both groups II and IV from a control of 5Μg/100 ml to 15Μg/100 ml 15 days after therapy. During this period of time the 4 arthritic dogs in group IV increased daily cage activity from 4 mile/day to 10 mile/day. Groups I, II, and III showed no increase or decrease in cage activity. No injections were given between day 60 and day 90. At 90, 97, 110 and 120 days, groups I and III were given bee venom and groups II and IV sterile saline. As before, bee venom increased plasma cortisol levels in both venom-treated groups and the daily cage activity in group III. At 120 days all injections were discontinued. Plasma cortisol levels returned to normal within 30 days, yet daily cage activity in both groups III and IV remained significantly above control (8 to 11 mile/day). Results indicate that whole bee venom stimulates the production of cortisol and the daily cage activity in dogs exhibiting arthritic-like conditions. No significant side effects were noted in any of the dogs treated with bee venom.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00917527
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  • 3
    Electronic Resource
    Electronic Resource
    Enantiomeric analysis of phenylpropanolamine in plasma via resolution of dinitrophenylurea derivatives on a high performance liquid chromatographic chiral stationary phase (1991)
    New York, NY : Wiley-Blackwell
    Biomedical Chromatography 5 (1991), S. 43-46 
    Details
    ISSN: 0269-3879
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Racemic phenylpropanolamine was resolved on a high performance liquid chromatographic (HPLC) chiral stationary phase (CSP) as the 3,5-dinitrophenyl ureide derivative. The CSP was prepared by a simple in situ procedure in which (R)-(1-naphthyl)ethyl isocyanate was bound to aminopropyl silanized silica through a urea linkage. The enantiomeric ureides were prepared by a room-temperature, 60-second procedure, accomplishing simultaneous extraction and derivatization and utilizing achiral 3,5-dinitrophenyl isocyanate as reagent. Baseline resolution was readily achieved under normal phase conditions, with a separation factor (α) of 1.16 and a resolution factor (Rs) of 2.2. Elution was complete within 10 min. A limit of detection, by UV at 235 nm, of 250 pg per isomer was established. Feasibility of the procedure for plasma determinations was demonstrated by assay of samples from a canine subject.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bmc.1130050110
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    Paper (German National Licenses)
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