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  • 1
    Electronic Resource
    Electronic Resource
    Mass fragmentographic determination of 3, 4 dihydroxyphenylethylamine and 4-hydroxy-3-methoxyphenylethylamine in the caudate nucleus (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 28 (1977), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1977.tb07774.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Automated metabolic profiling analysis of urinary steroids by a gas chromatography mass spectrometry data system (1983)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 10 (1983), S. 155-161 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A computer system (MSSMET), using methylene unit retention indices for an off-line reverse library search analysis of selected ion chromatograms from gas-liquid chromatographic mass spectrometric data, has been applied for the qualitative and quantitative determination of daily variations in the excreted levels of urinary steroids of two individuals, using capillary column gas-liquid chromatography. Aliquots of 24 h urine collections and morning spot urine samples were examined. The daily excretion pattern of most of the major steroid metabolites was fairly consistent from day to day (i.e. 3α-hydroxy-5α-androstane-17-one, androsterone; 3α-hydroxy-5β-androstane-17-one, etiocheolanolone; 3α, 17α,21-trihydroxy-5β-pregnane-11,20-dione, THE; 3α,11β,17α,21-tetrahydroxy-5β-pregnane-20-one, THF; 3α,11β,17α,21-tetrahydroxy-5α-pregnane-20-one; allo-THF; 3α,17α,20α,21-tetrahydroxy-5β-pregnane-11-one, cortolone; 3α,17α,20β,21-tetrahydroxy-5β-pregnane-11-one, β-cortolone; 5β-pregnane-3α,11β,17α,20α,21-pentol, cortol; 5β-pregnane-3α,11β,17α,20β,21-pentol,β-cortol), while certain other steroid metabolites had a less consistent excretion pattern (3β-hydroxy-5-androstene-17-one, for example). Advantages and disadvantages of using capillary columns for the automated metabolic profile analysis of urinary steroids by reverse library search of selected mass chromatograms.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200100309
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Utility of the parent-neutral loss scan screening technique: Partial characterization of urinary metabolites of U-78875 in monkey urine (1992)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 21 (1992), S. 517-522 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Metabolites of an antianxiety-sedative drug candidate (U-78875; 3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5-(1-methylethyl)-imidazo [1,5-α] quinoxalin-4(5H)-one (I)) present in the urine of monkeys were detected using tandem mass spectrometry (MS/MS) by application of parent ion scans and characterized or partially characterized by performing daughter ion scans of the pseudo-molecular ions of suspected metabolites. The use of liquid secondary ion mass spectrometry ionization of crude urinary extracts in combination with tandem quadrupole MS/MS analyses using parent ion scans of m/z 69 and subsequent daughter ion scans characterized unmetabolized I and N-dealkyl I (U-85466) and partially characterized aryl hydroxyl, aryl hydroxyl-N-dealkyl, aryl O-glucuronide, aryl O-glucuronide-N-dealkyl, aryl O-sulfate and aryl O-sulfate-N-dealkyl metabolites. From these data it was concluded that some of the metabolic pathways involved in the biotransformation of U-78875 include N-dealkylation, aryl hydroxylation and conjugation of aryl hydroxides. Several other metabolites of U-78875 not detected using this analytical approach were subsequently identified by alternative mass spectrometric approaches. These data clearly demonstrated both the utility and, just as important, the limitations of the parent-neutral loss scan screening technique in detecting drug metabolites in complex biological milieux.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200211009
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    Paper (German National Licenses)
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