ISSN:
0170-2041
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Description / Table of Contents:
Synthesis of Anhydrides in the A-Seco-steroid Series with 10β-Methyl or 10β-Methoxycarbonyl SubstitutionA-Seco- and A-nor-A-seco-dicarboxylic acids with cholestane skeleton and their anhydrides have been prepared in good yields from 2α-bromo-3-ketones by Baeyer-Villiger oxidation, dehydro-bromination of the resulting lactones, and oxidative cleavage of their double bond. 19-Functionalized A-nor-A-seco-steroid dicarboxylic acids have thus been obtained for the first time.
Notes:
A-Seco- und A-Nor-A-seco-dicarbonsäuren der Cholestanreihe und deren Anhydride wurden aus 2α-Brom-3-ketonen durch Baeyer-Villiger-Oxidation, Dehydrobromierung der erhaltenen Lactone und oxidative Spaltung derer Doppelbindung in guter Ausbeute dargestellt. 19-Funktionalisierte A-Nor-A-seco-steroiddicarbonsäuren wurden so erstmals zugänglich.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.197919790713
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