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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Cytokine 6 (1994), S. 552 
    ISSN: 1043-4666
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 24 (1986), S. 0 
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: With a bioassay sensitive for recombinant tumour necrosis factor at a concentration of 10-4 ng/ml, we were able to detect tumour necrosis factor-like cytotoxicity in serum from three patients in the initial phase of septicaemia. The cytotoxic activity corresponded in a concentration of recombinant tumour necrosis factor of 2x10-2-3x10-3 ng/ml serum. The concentration in cerebrospinal fluid was estimated lo be three limes higher than in serum. In 23 untreated patients with malignant disease of varying origin and stage, including two patients with severe cachexia, we were not able to detect tumour necrosis factor-like cytotoxicity.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 41 (1995), S. 0 
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Peripheral blood mononuclear ceils (PBMC) from six patients with paroxysmal nocturnal haemoglobinuria (PNH) were analysed by flow cytometry for expression of CD14 and for ability to respond to bacterial lipopolysaccharide and β 1–4 linked polymannuronic acid by TNF secretion. Expression of cell surface CD 14 could not be detected on cells from the PNH patients, whereas the levels of expression of other monocyte antigens, e. g. CD33 and CD13, were comparable to that of cells from healthy subjects. The cells from the patients with PNH responded with secretion of significantly less TNF after stimulation with LPS and polymannuronic acid than mononuclear cells from healthy subjects, suggesting an impaired ability in PNH to respond to bacterial infection by TNF secretion from monocytes. Soluble CD 14 appeared to be involved in the residual activation of CD14 negative PBMC, and the sera of these patients contained normal or slightly elevated levels of soluble CD 14. After allogeneic bone marrow transplantation in one patient the monocytes expressed CD 14 at normal levels and responded normally with respect to their ability to generate TNF upon stimulation.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Surgical endoscopy and other interventional techniques 12 (1998), S. 852-855 
    ISSN: 1432-2218
    Keywords: Key words: Bile duct injury — Cholecystectomy — National registry — Patient volume — Surgical complications — Treatment quality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: A registry was initiated in order to establish national standards for the quality of surgical treatment of gallstones, and to provide feedback to all hospitals about serious complications, in order to reduce their future incidence. Methods: Prospective registration of complications was performed at all hospitals and collected in the National Norwegian Cholecystectomy Registry (NNCR) over a period of 33 months. Results: Open cholecystectomy (OC) was performed in 1011 patients, and laparoscopic cholecystectomy (LC) in 4332 patients. These figures represent 68% of all procedures performed nationally. The frequency of bile duct (BD) injury was 0.8% for LC versus 0.7% for OC (ns); mortality was 0.1% versus 2.1%, respectively (p 〈 0.05). The frequency of BD injury and mortality were added; the sum comprised the Severe Complication Index (SCI). A linear relationship was found between SCI and patient volume (correlation coefficient, r2 2= 0.78). Conclusions: SCI was found to be the best indicator of surgical success. We have proposed its use as a parameter for a future prospective quality assurance program, along with patient volume.
    Type of Medium: Electronic Resource
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