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  • 1
    Electronic Resource
    Electronic Resource
    The measurement of histamine release from suspensions of rat peritoneal cells rich in mast cells (1977)
    Springer
    Inflammation research 7 (1977), S. 431-436 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Histamine released from the mast cells in unfractionated rat peritoneal cell suspensions could be quickly and conveniently measured by an automated chemical method. There were no substances in the unfractionated peritoneal cells that interfered with the chemical histamine measurement. Organic extraction of histamine and deproteinization of samples were not necessary using the automated method. The amount of histamine released from preparations of peritoneal cells by a fixed concentration of compound 48/80 decreased with the time of preincubation of the cells but this varied between preparations. Phagocytic, activity directed against the mast cells probably explained these observations. The state of nutrition of the rats and the presence or absence of albumin and/or glucose in the medium all influenced the rate of decline of viability of the mast cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966848
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  • 2
    Electronic Resource
    Electronic Resource
    Vascular Hyper-reactivity with Sodium Loading and with Deoxycorticosterone Induced Hypertension in the Rat (1970)
    [s.l.] : Nature Publishing Group
    Nature 227 (1970), S. 1141-1142 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Three groups of seven male Wistar rats were studied. Animals in one group were left intact and received a normal diet and tap water. Rats in the two remaining groups had one kidney removed and were given 1 per cent NaCl and 0-2 per cent KC1 to drink. After two months, 12-5 mg deoxycorticosterone ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2271141a0
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  • 3
    Electronic Resource
    Electronic Resource
    METOCLOPRAMIDE AS A DOPAMINE ANTAGONIST IN THE HEART AND GUT OF THE MOLLUSC TAPES WATLINGI (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 1 (1974), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY 1. Metoclopramide is a potent antagonist of the inhibitory response to dopamine in two isolated tissues, the electrically stimulated intestine and the spontaneous beating heart, from the mollusc Tapes watlingi.2. Blockade by metoclopramide of dopamine receptors in the central nervous system of man may account for the relapse of patients with Parkinson's disease which occurs when metoclopramide is given during successful therapy with levodopa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1974.tb00568.x
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  • 4
    Electronic Resource
    Electronic Resource
    EFFECTS OF VARIOUS DRUGS ON THE OSMOTIC LYSIS OF RAT MAST CELLS (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 5 (1978), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Rat mast cells were exposed to low osmotic pressures to produce a ‘nonspecific’ disruption of the mast cell, with release of histamine along with other intracellular contents.2. The effect of non-steroidal anti-inflammatory drugs and various other drugs upon osmotically induced histamine release was examined.3. Representative non-steroidal anti-inflammatory drugs indomethacin, phenylbutazone and flufenamic acid, the acidic compounds ethacrynic acid, iopanoic acid and probenecid, and the local anaesthetic lignocaine, all caused a dose-dependent facilitation of osmotically induced histamine release compared to controls. All drugs were active at 0.1 mmol/1.4. The previously observed inhibition of compound 48/80 and the antigen-induced histamine release from rat mast cells by similar concentrations of the drugs used in the present study are unlikely to be due to mast cell plasma membrane stabilization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1978.tb00700.x
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  • 5
    Electronic Resource
    Electronic Resource
    DIFFERENTIAL BLOCKADE OF OCTOPAMINE AND DOPAMINE RECEPTORS BY ANALOGUES OF CLOZAPINE AND METOCLOPRAMIDE (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 5 (1978), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Sulpiride, but not procainamide, antagonizes the excitatory effects of (±)-octopamine receptors in the Tapes ventricle. Neither compound attenuates dopamine excitation.2. Clozapine will attenuate the effects of (±)-octopamine and (-)-α-methyl octopamine at the octopamine receptor but not the excitatory effects of dopamine at dopamine receptors.3. Clozapine is more potent than its 2-positional isomer HF 2046 in attenuating octopamine excitation. However, HF 2046, unlike clozapine, will attenuate the excitatory effects of dopamine.4. These data indicate that replacement of the 8-chloro substituent in the clozapine nucleus with a 2-chloro substituent decreases the ability of the compound to blockade octopamine receptors. However, the 2-chloro-substituted compound (HF 2046) now has the added ability to blockade excitatory dopamine receptors.5. The greater potency of clozapine than HF 2046 as an octopamine antagonist suggests that it is the 8-chloro-substituted aromatic ring of clozapine which overlaps the aromatic site usually occupied by the octopamine aromatic ring.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1978.tb00683.x
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  • 6
    Electronic Resource
    Electronic Resource
    ACTION OF OCTOPAMINE AGONISTS AND STEREO ISOMERS AT A SPECIFIC OCTOPAMINE RECEPTOR (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 5 (1978), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. (±)-Octopamine, (±)-N-methyl octopamine and (-)-α-methyl octopamine increase the amplitude of contraction of the spontaneously beating ventricle of the mollusc Tapes watlingi through action on a specific octopamine receptor.2. Unlike the excitatory responses to dopamine, noradrenaline or serotonin, the excitatory response of the ventricle to agonists at the octopamine receptor is attenuated by metoclopramide.3. Compounds with potent agonist activity at the octopamine receptor all have a single phenolic hydroxyl in the para position of the benzene ring and a β-hydroxyl group in the phenethylamine side chain. O-Methylation of the para phenolic group or removal of the /3-hydroxyl group results in complete loss of agonist activity. Bulky substituents but not a single methyl group on the amino groups impair agonist activity.4. The octopamine receptor is stereo-selective, (-)-octopamine is more than twenty times more active than (+)-octopamine.5. The weak octopamine-like activity of (-)-N-methyl and a-methyl meta octopamine indicates that the stereo-selective receptor has a relative rather than an absolute requirement for a single phenolic hydroxyl in the para position of the benzene ring.6. These data indicate the presence of a specific, stereo-selective receptor for octopamine in the ventricle of the mollusc Tapes watlingi.7. The stereo-selectivity and structural specificity of the octopamine receptor differentiates it from receptors for dopamine and serotonin also present in the ventricle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1978.tb00682.x
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  • 7
    Electronic Resource
    Electronic Resource
    Nucleotide requirement of dopamine sensitive adenylate cyclase in synaptosomal membranes from the striatum of rat brain (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 27 (1976), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1976.tb02640.x
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  • 8
    Electronic Resource
    Electronic Resource
    Active Transport of L -Dopa in the Intestine (1973)
    [s.l.] : Nature Publishing Group
    Nature 242 (1973), S. 463-465 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Male Sprague-Dawley rats (250-300 g) fed ad lib. were killed by a blow on the head. The small intestine between the common bile duct and the caecum was removed quickly, washed through with 20 ml. of normal saline and everted on a length of polythene tubing. Within 5 min of the death of the animal, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/242463a0
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  • 9
    Electronic Resource
    Electronic Resource
    Iminoglycinuria — A “harmless” inborn error of metabolism? (1968)
    Springer
    Human genetics 〈Berlin〉 6 (1968), S. 362-367 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A boy with iminoglycinuria was discovered during routine urinary amino acid screening of a series of children with severe visual handicap. In addition to iminoglycinuria and blindness due to Leber's tapeto-retinal degeneration, this boy has profound perceptive deafness dating from infancy. It is concluded, on the basis of a study of previous cases reported, that the iminoglycinuria is not causally related to his blindness and deafness and may represent an essentially harmless inborn error of metabolism. The view that he suffers from three distinct autosomal recessive conditions receives some support from the fact that he may be the offspring of a mating between full sibs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00286806
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  • 10
    Electronic Resource
    Electronic Resource
    Plasma quantitation of warfarin and warfarin alcohol by gas chromatography chemical ionization mass spectrometry in patients on warfarin maintenance therapy (1979)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 6 (1979), S. 208-211 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A quantitative method has been developed to measure plasma concentrations of warfarin and warfarin alcohol. The analytical procedure uses deuterated analogues as internal standards, and the technique of selected ion monitoring following gas chromatography methane chemical ionization mass spectrometry of the 4′-methyl ethers of warfarin and warfarin alcohol. Concentrations of warfarin and warfarin alcohol have been measured in plasma samples from 43 patients maintained on chronic warfarin therapy and compared with the ‘apparent warfarin’ concentration as measured by a fluorometric procedure. The study demonstrated a high degree of correlation between the gas chromatographic mass spectrometric derived sum of the individual concentrations of warfarin and warfarin alcohol, and the ‘apparent warfarin’ concentration determined from a spectrofluorometric assay.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200060508
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