ISSN:
0947-3440
Keywords:
Enzymes
;
Peptide conjugates
;
Protecting groups
;
Bioorganic chemistry
;
Enzyme catalysts
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Glyco-, phospho-, nucleo- and lipoproteins play key roles in biological signalling cascades, by which chemical signals are passed across the cell membrane and further to the cell nucleus. For the study of the biological phenomena associated with these protein conjugates, structurally well-defined peptides containing the characteristic linkage region of the peptide backbone with the carbohydrate, the lipid or the phosphoric acid ester can be applied advantageously. The multifunctionality and the pronounced acid- and base-lability of lipo-, phospho-, nucleo- and glycopeptides, however, renders their synthesis a formidable challenge to conventional organic synthesis. This review highlights the potential of enzymatic transformations, in particular for the removal of protecting groups, as central techniques for the construction of complex and sensitive biologically relevant peptide conjugates under particularly mild conditions and with high selectivity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199719970504
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