ISSN:
0020-7608
Keywords:
Computational Chemistry and Molecular Modeling
;
Atomic, Molecular and Optical Physics
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Quantum mechanical tunneling theory is applied to the problem of synaptic vesicle release and to the problem of electric transmission at the ephaptic junction. In the synapse the tunneling produces conformational changes in macromolecules to open and close vesicle macrogates. Quantum mechanical tunneling as a basis for charge transfer and physical release of vesicles at junction membranes provides a unified concept of ephaptic and synaptic transmission. Details of this model are in agreement with experimental data for miniature endplate potential frequency and delay effects as a function of polarization, osmotic pressure, and temperature. The theory accounts for anatomical specializations at the synaptic cleft and the narrow junction observed for the ephapse.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/qua.560110109
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