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  • 1
    ISSN: 1432-2277
    Keywords: Keywords Renal transplant ; Hemolytic-uremic syndrome ; Cyclosporine ; Tacrolimus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hemolytic-uremic syndrome (HUS) is a well-recognized complication of cyclosporine (CyA) therapy. Transplant recipients with this complication are frequently switched to tacrolimus, although this drug has also been implicated. We report a case of a renal transplant recipient who developed severe graft dysfunction due to biopsy-proven HUS after receiving CyA. Renal function and hemolytic parameters improved with discontinuation of the drug, but they deteriorated again after commencement of tacrolimus 15 days later. A second transplant biopsy demonstrated fresh lesions diagnostic of HUS. Hemolytic parameters resolved with discontinuation of tacrolimus. This is the first report of metachronous HUS being caused in a renal transplant by both CyA and tacrolimus. We therefore believe that caution should be exercised when using tacrolimus as rescue therapy in patients with CyA-induced HUS.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Transplant international 6 (1993), S. 39-41 
    ISSN: 1432-2277
    Keywords: Donor age ; kidney transplantation — Kidney transplantation ; older donors — Cyclosporin ; older donors ; kidney transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Reluctance to use kidneys from older donors (〉50 years of age) is based on reports of inferior results. We reviewed our experience with 45 kidneys transplanted from older donors. Primary nonfunction, immediate graft function, and 1-, 2- and 3-year graft survival rates were similar to those obtained with kidneys transplanted from donors aged between 20 and 40 years. Renal function at 1 year (as measured by serum creatinine) was poorer in kidneys from older donors. No beneficial effect with respect to graft survival was noted with cyclosporin therapy compared to conventional immunosuppression; however, the numbers are small. We conclude that kidneys from older donors are a valuable source for transplantation.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    International urology and nephrology 16 (1984), S. 101-107 
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of a pre-aortic left renal vein compression by the aorta is reported. The clinical presentation was characterized by the left flank pain varying with body position. Renal venography was crucial for the diagnosis of this lesion. The left renal vein was successfully decompressed by ovarian vein-vena cava shunt surgery. The patient's left flank pain subsided after the surgery. This is the first reported case of a left renal vein compression syndrome by the aorta following the nephrotic syndrome.
    Type of Medium: Electronic Resource
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