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  • 1
    ISSN: 1524-475X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Tissue engineering is an application for gene therapy that is in its infancy. We show that simple liposomal-mediated gene transfer could result in a potentially useful biological effect in the field of wound healing. cDNA encoding the 165 amino acid form of vascular endothelial growth factor complexed to commercially available liposomes was injected into rat skin 1 week before raising a random pattern 3 × 10 cm flap. The flap survival was enhanced by 14 percent, and was accomplished without accessing the arterial inflow of the territory. These results were statistically significant (p 〈 0.002) and reproducible. No adverse effects were seen. Histological analysis of the angiogenesis localized much of the new vessel formation to the area around the hair follicles. Polymerase chain reaction amplification of extracted flap tissue confirmed the presence of the transgene.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Psychophysiology 28 (1991), S. 0 
    ISSN: 1469-8986
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin , Psychologie
    Notizen: Event-related potentials (ERPs) and behavioral ratings were collected from 30 female subjects who were exposed to picture slides. The slides belonged to five affective categories whose content was babies, dermatological cases, ordinary people, male models, and female models. Based on the day of testing relative to their menstrual cycle, the subjects were grouped according to their expected levels of androgens, estrogen, or progesterone. The data were examined to determine whether any ERP component or behavioral rating (non-erotic/erotic, unpleasant/pleasant, simple/complex, and low arousal/high arousal) varied as a function of subjects' hormone defined menstrual phase. Only the P3 component was sensitive to menstrual phase. The P3 to babies and male models was largest when progesterone levels were high. High progesterone was also associated with a decrease in the complexity and eroticism of all slide categories. An increase in the pleasantness of all categories was evident when estrogen levels were high. The results are interpreted as support for an “adaptive context updating” theory of the P3 component of ERPs.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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