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  • 1
    Electronic Resource
    Electronic Resource
    Cold panniculitis – an unusual differential diagnosis from aluminium allergy in a patient hyposensitized with aluminium-precipitated antigen extract (2001)
    Copenhagen : Munksgaard International Publishers
    Contact dermatitis 44 (2001), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0536.2001.044006366-3.x
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  • 2
    Electronic Resource
    Electronic Resource
    Tolerance to intravenous admiration of heparin and heparinoid in a patient with delayed-type hypersensitivity to heparins and heparinoids (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 35 (1996), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Delayed-type hypersensitivity reactions ot subcutaneously (s.c) injected heparins are common. Since similar reactions usually occur to different heparin preparations, semisynthetic heparinoids might be a therapeutic alternative. We report a patient exhibiting eczematous reactions to heparins as well as heparinoids; delayed-type hypersensitivity was demonstrated by intracutaneous (i.c.) and patch tests, as well as by s.c. provocation. Remarkably, intravenous (i.v.) administration of heparin as well as heparinoid was well-tolerated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1996.tb02293.x
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  • 3
    Electronic Resource
    Electronic Resource
    Cutaneous angiosarcoma afflicting the lower aspect of the left leg in an elderly woman (2000)
    Oxford, UK : Blackwell Science Ltd
    International journal of dermatology 39 (2000), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An 88-year-old woman who was generally in good health was referred to the Dermatology Department in August 1997. Three years prior to admission she had first noticed a bluish macule on her left lower leg which had rapidly enlarged over the past 3 months. Other symptoms included intermittent bleeding and pain. On examination, there was an exophytic and partly exulcerated tumor of approximately 9 × 7 cm in diameter, located above the left medial malleolus. The remainder of the lower aspect of the left leg was without pathologic findings. The patient had not undergone surgery or radiotherapy prior to the described symptoms.Blood hematology, chemistry, immunologic and serologic parameters (including liver function tests) were within the normal range. The alkaline phosphatase decreased from 211 U/L initially to 179 U/L. Magnetic resonance imaging (MRI) of the left lower leg revealed a 10 × 5 × 2 cm tumor mass invading the subcutaneous fat, leaving muscle tissue. Ultrasound of the regional lymph nodes, a chest X-ray, and a full-chest computed tomography (CT) scan were normal. A biopsy specimen showed a marked proliferation of cells of undifferentiated morphology in the corium and subcutaneous tissue. Several layers of atypical endothelial cells next to large cuboid cells with pleomorphic nuclei and frequent mitoses were noted, thus facilitating clear differentiation from Kaposi’s sarcoma ( 〈link href="#f1"〉Fig. 1). Immunohistochemical studies were positive for factor VIII-related antigen, ulex europaeus I, CD31, and CD34. An angiosarcoma was diagnosed.〈figure xml:id="f1"〉1 A〈mediaResource alt="image" href="urn:x-wiley:00119059:IJD981-1:IJD_981-1_f1"/〉biopsy specimen showing marked proliferation of atypical endothelial cells in the corium and subcutaneous tissueTreatment included a complete surgical excision of the tumor with a wide safety margin of normal tissue. The skin defect was covered with mesh-graft. At this point, the patient refused consent to adjuvant radiation therapy postoperatively.In January 1998 and in March 1998 recurrences of the tumor were again treated with local excision and mesh-graft. Subsequent to multifocal recurrence in June 1998 ( 〈link href="#f2"〉Fig. 2A), the patient finally accepted palliative radiotherapy. Fractionated irradiation (total dose/left lower leg: 50 Gy; single fraction dose/left lower leg: 2 Gy; 6 MV photons) resulted in local control of the lesion for more than 6 months. In January 1999, another local recurrence of the tumor was treated with the cw-Nd:YAG laser technique as it was not possible to conduct a second course of radiation therapy. Only 1 month later the patient presented again with multifocal spread involving most of the left lower leg ( 〈link href="#f2"〉Fig. 2B). Considering the patient's age and nursing circumstances, an above-knee amputation of the left leg was performed.〈figure xml:id="f2"〉2(A)〈mediaResource alt="image" href="urn:x-wiley:00119059:IJD981-1:IJD_981-1_f2"/〉Multifocal recurrence in June 1998. (B) Progression of the disease with ulceration in February 1999
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-4362.2000.00981-1.x
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  • 4
    Electronic Resource
    Electronic Resource
    Molecular Defects of Collagen Metabolism in the Ehlers-Danlos Syndrome (1981)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 20 (1981), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1981.tb02005.x
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  • 5
    Electronic Resource
    Electronic Resource
    Immunofluorescent localization of type IV collagen and laminin in human skin and its application in junctional zone pathology (1982)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 106 (1982), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Purified antibodies against type IV collagen and laminin were used to localize basement membranes by indirect immunofluorescence in various anatomical regions of normal and diseased human skin. The two proteins showed extensive codistribution. A continuous linear staining was found along the epidermal-dermal junction and around hair follicles, sebaceous gland acini and small capillaries. The same proteins also surrounded individual cells such as those found in vessels, hair erector muscles and subcutaneous tissue.Blister formation in bullous pemphigoid left type IV collagen and laminin on the floor of the blister, while the bullous pemphigoid antigen as detected by human autoantibodies was found on both sides of the blister. In solid basal cell carcinoma a strong staining was found around all tumour islands as well as focally within the cell clusters. This suggests that the tumour cells produce these basement membrane proteins but have lost, at least in part, control of polar deposition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1982.tb01722.x
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  • 6
    Electronic Resource
    Electronic Resource
    Zuordnung offenkettiger Diastereomerer mittels lanthanoiden-induzierter Verschiebungen (LIS) (1988)
    Springer
    Monatshefte für Chemie 119 (1988), S. 1011-1017 
    Details
    ISSN: 1434-4475
    Keywords: LIS method ; Coordination geometry Eu ... O ; Conformational analysis ; Assignment of flexible diasteroisomers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The LIS method has been tested for assignment purposes of acyclic diastereomers. After the estimation of the coordination geometry Eu ... O for some alkyl-methyl-ethers, the ground state conformations of the coordinated substrates have been determined and related to the free substrates. Due to obtained differences, the application of the LIS method for present assignment purposes should be limited to strained, less flexible stereoisomers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00810109
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  • 7
    Electronic Resource
    Electronic Resource
    Dermal architecture and collagen type distribution (1977)
    Springer
    Archives of dermatological research 259 (1977), S. 1-10 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An der menschlichen Dermis lassen sich morphologisch zwei verschiedene Schichten unterscheiden. Ein lockeres Maschenwerk aus dünnen kollagenen Fasern ist charakteristisch für die adventitielle Dermis, welche die papilläre und die periadnexielle Dermis einschließt. Dicke, plumpe Kollagenfaserbündel sind das Hauptmerkmal der retikulären Dermis. Biochemisch können die beiden Kollagentypen I und III in der menschlichen Dermis nachgewiesen werden. Typspezifische Antikörper gegen Typ I Kollagen, Typ III Kollagen und die entsprechenden Prokollagene erlauben in der indirekten Immunofluorescenztechnik an Gefrierschnitten von normaler Erwachsenenhaut eine Lokalisation der genetisch differenten Kollagene. Typ I Kollagen wird in allen Schichten gefunden, Typ III Kollagen ist mit seinem Hauptanteil auf die adventitielle Dermis beschränkt. Antikörper gegen Prokollagen Typ I färben nur eine schmale bandförmige Zone unmittelbar unterhalb der Epidermis. Antikörper gegen Prokollagen Typ III reagieren innerhalb derselben Bereiche der Dermis wie Antikörper gegen den helikalen Anteil von Typ III Kollagen.
    Notes: Summary The human dermis consists of two morphologically different layers. A loose meshwork of thin collagenous fibres is characteristic for the adventitial dermis with includes the papillary and the periadnexal dermis. Thick, coarse collagen bundles are the main feature of the reticular dermis. Two different collagens, type I and type III occur in the dermis as shown previously by biochemical analyses. Antibodies specific for type I collagen or type III collagen and their corresponding precursors were used in indirect immunofluorescence tests to localize the various collagens in frozen sections of normal adult skin. Whereas type I collagen is found in all dermal layers, the main part of type III collagen can be found within the adventitial dermis. Antibodies against the precursor of type I collagen stain only a bandlike region immediately beneath the epidermis. Antibodies against the precursor of type III collagen stain the same regions as antibodies against the helical part of type III collagen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562732
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  • 8
    Electronic Resource
    Electronic Resource
    Sexual dimorphism of newborn mouse epithalamus after fractionated X-irradiation at late stage of organogenesis (1980)
    Springer
    Virchows Archiv 389 (1980), S. 43-57 
    Details
    ISSN: 1432-2307
    Keywords: Epithalamus ; X-irradiation ; Fetus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fractionated X-irradiation with 3×0.95, 3×1.05, 3×1.15, or 3× 1.35 Gy on gestational days 11–13 in the mouse results in two discrete, clearly distinguishable forms of an epithalamic malformation observable on gestational day 18. Type A is characterized by a rhombic shape of the dorsal diencephalic sulcus which first narrows at the occipital edge. The habenular diameters in the plane of the habenular commissure are in the range between 81 and 88% of the control measurements. The anterior colliculi are quite well developed. The type B lesion is characterized by a rather narrow epithalamus with a sandglass-shaped dorsal diencephalic sulcus and habenular diameters that are only about 56 to 64% of the control values. With the exception of the group with the lowest radiation dose (3×0.95 Gy), the type B lesion predominates. The B∶A ratios are 1.5 and 1.6 in the highest dosage groups, and show the most drastic increase to a ratio of 4.0 after application of 3×1.05 Gy. Type B lesions occur in female fetuses at a higher frequency than in males and thus shows a clear-cut correlation with the frequency and severity of neocortical lesions in the same individuals. This is again most marked in the 3×1.05 Gy dosage group, where the type B lesion occurs five times more frequently in females than in males. This sexual dimorphism in the reaction pattern of the epithalamus after X-irradiation in utero, can best be explained by postulating a causal link with the forebrain lesions which were recently shown to exhibit similar sexual dimorphism. We therefore postulate a retrograde transsynaptic degeneration of the thalamo-cortical fibres that develop pre-term, which is significantly expressed only after a low X-irradiation dose, but is partly abolished in the higher dosage groups. This leads to hypoplastic alterations of the epithalami, a secondary phenomenon to the neocortical lesions in the animals most affected. The resulting dysfunction of the epithalamus in the immediate neonatal period is then responsible for the preferential death of the animals with B-type lesions and also explains why female mortality is significantly higher than male mortality which occurs only in the 3×1.05 Gy dosage group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428667
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  • 9
    Electronic Resource
    Electronic Resource
    Collagen polymorphism in pathologic human scars (1978)
    Springer
    Archives of dermatological research 261 (1978), S. 63-71 
    Details
    ISSN: 1432-069X
    Keywords: Collagen polymorphism ; Pathologic human scars ; SDS disc electrophoresis ; Kollagen Polymorphismus ; Pathologische Narben beim Menschen ; SDS-Diskelektrophorese
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Kollagentypzusammensetzung normaler und pathologischer Narben wird im Vergleich zur unveränderten Haut des gleichen Individuums untersucht. Nach histologisch kontrollierter Präparation werden die Gewebeproben mit Bromcyan abgebaut. Die elektrophoretischen Verteilungsmuster der BrCN-Peptide in 12%igen SDS-Polyacrylamidgelen erlauben den Rückschluß auf das Vorhandensein von Typ I und Typ III Kollagen. Die Intensität der Typ III spezifischen Peptidbanden korreliert mit dem Typ III-Gehalt der Proben. Mit dieser Methode kann in normalen und pathologischen Narben sowohl Typ I als auch Typ III Kollagen nachgewiesen werden. Der Typ III-Gehalt älterer normaler Narben ist gering erhöht, der Typ III-Gehalt pathologischer Narben ist deutlich erhöht im Vergleich zum Typ III-Gehalt der Normalhaut. Pathologisches Narbengewebe zeigt in der SDS-Diskelektrophorese ein entsprechendes Peptidverteilungsmuster wie Fötalhaut. Beide unterscheiden sich deutlich vom Peptidmuster der normalen Erwachsenenhaut.
    Notes: Summary The collagen type composition of normal and pathologic scars was examined in comparison with normal skin from the same individual. Particular care was taken to separate scar tissue from adjacent normal dermis. After urea extraction, the tissue specimens were cleaved with cyanogen bromide. The presence of the dermal collagen types I and III was deduced from the electrophoretic distribution patterns of the CNBr peptides in 12% SDS-polyacrylamide gels. The intensity of the type III specific peptide bands correlates with the type III content of the samples. Using this method, the presence of both type I and type III collagen can be proved in normal as well as pathologic scars. The type III content in older normal scars is slightly increased, whereas the type III content of pathologic scars is significantly increased in comparison with the type III content of normal skin. The electrophoretic CNBr peptide distribution pattern of pathologic scar tissue is almost the same as that of fetal skin. Both are clearly different from the peptide pattern of normal adult skin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455376
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  • 10
    Electronic Resource
    Electronic Resource
    SDS-polyacrylamide gel electrophoretic (1977)
    Springer
    Archives of dermatological research 258 (1977), S. 251-257 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird eine Dodecylsulfat-Polyacrylamidgel-elektrophoretische Methode beschrieben, mit welcher der Gehalt an Typ I- und Typ III-Kollagen in kleinen Hautproben, z. B. Probebiopsien, bestimmt werden kann. Im Gegensatz zu anderen biochemischen Methoden, z. B. der Salzpräzipitation oder der Ionenaustausch- und Molekularsiebchromatographie, ist diese Methode zur Darstellung kleinster Peptidmengen geeignet. Harnstoffextrahierte Gewebeproben werden mit Bromcyan abgebaut. Die hierbei freigesetzten, den einzelnen α-Ketten zugeordneten Bromcyan-Peptide werden in 12%igen Gelen aufgetrennt. Aus den densitometrischen Kurvenverläufen der gelelektrophoretischen Peptidverteilungsmuster wird auf den Kollagentypgehalt der untersuchten Gewebeproben geschlossen. Beim Vergleich von Fötalhaut mit Erwachsenenhaut kann der höhere Typ III-Gehalt der Fötalhaut dargestellt werden.
    Notes: Summary A sodium dodecylsulfate-polyacrylamide electrophoretic method, which in contrast to other biochemical procedures, e. g. differential salt precipitation or ion exchange chromatography and molecular sieve chromatography, is applicable to smallest amounts of protein, is shown to be suitable for the determination of the collagen types from small skin samples, such as routine skin biopsies. After urea extraction, the tissue samples are cleaved with cyanogen bromide. The resulting CNBr peptides derived from the different α-chains are resolved in 12% SDS-polyacrylamide gels. Densitometric profiles of the gel electrophoretic patterns correspond to the collagen type content of the tissue specimens. Comparing fetal to adult skin, the higher content of type III collagen in the case of fetal skin can be demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561127
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