Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    ESTIMATING F-STATISTICS (2002)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Genetics 36 (2002), S. 721-750 
    Details
    ISSN: 0066-4197
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract A moment estimator of theta, the coancestry coefficient for alleles within a population, was described by Weir & Cockerham in 1984 (100) and is still widely cited. The estimate is used by population geneticists to characterize population structure, by ecologists to estimate migration rates, by animal breeders to describe genetic variation, and by forensic scientists to quantify the strength of matching DNA profiles. This review extends the work of Weir & Cockerham by allowing different levels of coancestry for different populations, and by allowing non-zero coancestries between pairs of populations. All estimates are relative to the average value of theta between pairs of populations. Moment estimates for within- and between-population theta values are likely to have large sampling variances, although these may be reduced by combining information over loci. Variances also decrease with the numbers of alleles at a locus, and with the numbers of populations sampled. This review also extends the work of Weir & Cockerham by employing maximum likelihood methods under the assumption that allele frequencies follow the normal distribution over populations. For the case of equal theta values within populations and zero theta values between populations, the maximum likelihood estimate is the same as that given by Robertson & Hill in 1984 (70). The review concludes by relating functions of theta values to times of population divergence under a pure drift model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.genet.36.050802.093940
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The Effects of Inbreeding on Forensic Calculations (1994)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Genetics 28 (1994), S. 597-621 
    Details
    ISSN: 0066-4197
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ge.28.120194.003121
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Introduction (1995)
    Springer
    Genetica 96 (1995), S. 1-2 
    Details
    ISSN: 1573-6857
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01441145
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    A comparison of tests for independence in the FBI RFLP data bases (1995)
    Springer
    Genetica 96 (1995), S. 125-138 
    Details
    ISSN: 1573-6857
    Keywords: Hardy-Weinberg ; forensic databasses ; statistical tests ; FBI data
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Several tests of independence of alletic frequencies within and between loci have been compared, and it has been found that Fisher's exact test is the best test to use. When this test is applied to RFLP databases established by the FBI, paying no attention to the single-band problem, there is generally evidence for independence at one locus but not at two loci. When the test is restricted to double-banded entries in the databases; there is overall evidence for independence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01441158
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Exact tests for association between alleles at arbitrary numbers of loci (1995)
    Springer
    Genetica 96 (1995), S. 169-178 
    Details
    ISSN: 1573-6857
    Keywords: exact tests ; allelic association ; Hardy-Weinberg ; linkage disequilibrium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Associations between allelic frequencies, within and between loci, can be tested for with an exact test. The probability of the set of multi-locus genotypes in a sample, conditional on the allelic counts, is calculated from multinomial theory under the hypothesis of no association. Alleles are then permuted and the conditional probability calculated for the permuted genotypic array. The proportion of arrays no more probable than the original sample provides the significance level for the test. An algorithm is provided for counting genotypes efficiently in the arrays, and the powers of the test presented for various kinds of association. The powers for the case when associations are generated by admixture of several populations suggest that exact tests are capable of detecting levels of association that would affect forensic calculations to a significant extent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01441162
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    DNA profiling on trial (1994)
    [s.l.] : Nature Publishing Group
    Nature 369 (1994), S. 351-351 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR — Balding and Donnelly1 consider that courts have been misled about the strength of DNA evidence. But although they make the correct distinction between the probability that a particular individual has the DNA profile in question and the probability that he has this profile given that ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/369351c0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Age of the ΔF508 cystic fibrosis mutation (1994)
    [s.l.] : Nature Publishing Group
    Nature genetics 8 (1994), S. 216-216 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Sir—In a recent Nature Genetics paper, Morral et al. suggested that the ΔF508 mutation, responsible for 70% of the cases of cystic fibrosis (CF), is at least 2,600 generations old. This is far greater than the usually accepted figure of a few hundred generations2. Morral et al. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1194-216a
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Two-locus inbreeding measures for recurrent selection (1977)
    Springer
    Theoretical and applied genetics 49 (1977), S. 63-77 
    Details
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary For a population undergoing recurrent selection, a method is presented for determining the average inbreeding coefficients at the end of each breeding cycle. The coefficients are derived in terms of probability measures that genes are identical by descent. For the one-locus case, two digametic measures are defined and employed in the derivation of a recurrence formula for the inbreeding coefficient. Two further classes of measures, trigametic and quadrigametic, are required for transition from one cycle to the previous one to allow the calculation of the inbreeding function for the two-locus case. Numerical values of the average probability of double identity by descent for populations with various imposed assumptions are listed to illustrate the effects of linkage and population size on the accrual of inbreeding and hence of homozygosity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00275165
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Diallel analysis for sex-linked and maternal effects (1996)
    Springer
    Theoretical and applied genetics 92 (1996), S. 1-9 
    Details
    ISSN: 1432-2242
    Keywords: Diallel analysis ; Sex-linked and maternal effects ; Variance and covariance components ; Genetic prediction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Genetic models including sex-linked and maternal effects as well as autosomal gene effects are described. Monte Carlo simulations were conducted to compare efficiencies of estimation by minimum norm quadratic unbiased estimation (MINQUE) and restricted maximum likelihood (REML) methods. MINQUE(1), which has 1 for all prior values, has a similar efficiency to MINQUE(θ), which requires prior estimates of parameter values. MINQUE(1) has the advantage over REML of unbiased estimation and convenient computation. An adjusted unbiased prediction (AUP) method is developed for predicting random genetic effects. AUP is desirable for its easy computation and unbiasedness of both mean and variance of predictors. The jackknife procedure is appropriate for estimating the sampling variances of estimated variances (or covariances) and of predicted genetic effects. A t-test based on jackknife variances is applicable for detecting significance of variation. Worked examples from mice and silkworm data are given in order to demonstrate variance and covariance estimation and genetic effect prediction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222944
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Analysis of cytoplasmic and maternal effects I. A genetic model for diploid plant seeds and animals (1994)
    Springer
    Theoretical and applied genetics 89 (1994), S. 153-159 
    Details
    ISSN: 1432-2242
    Keywords: Modified diallel crosses ; Monte Carlo simulation ; Cytoplasmic and maternal effects ; Variance and covariance components ; Genetic prediction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A genetic model for modified diallel crosses is proposed for estimating variance and covariance components of cytoplasmic, maternal additive and dominance effects, as well as direct additive and dominance effects. Monte Carlo simulations were conducted to compare the efficiencies of minimum norm quadratic unbiased estimation (MINQUE) methods. For both balanced and unbalanced mating designs, MINQUE (0/1), which has 0 for all the prior covariances and 1 for all the prior variances, has similar efficiency to MINQUE(θ), which has parameter values for the prior values. Unbiased estimates of variance and covariance components and their sampling variances could be obtained with MINQUE(0/1) and jackknifing. A t-test following jackknifing is applicable to test hypotheses for zero variance and covariance components. The genetic model is robust for estimating variance and covariance components under several situations of no specific effects. A MINQUE(0/1) procedure is suggested for unbiased estimation of covariance components between two traits with equal design matrices. Methods of unbiased prediction for random genetic effects are discussed. A linear unbiased prediction (LUP) method is shown to be efficient for the genetic model. An example is given for a demonstration of estimating variance and covariance components and predicting genetic effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225135
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...