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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Langmuir 9 (1993), S. 1446-1448 
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1420-908X
    Keywords: Antiinflammatory ; Analgesia ; Cyclooxygenase-1 ; Cyclooxygenase-2 ; Tenidap
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tenidap is a new anti-rheumatic agent which has clinical properties characteristic of a disease modifying drug combined with acute antiinflammatory and analgesic activity. This paper details tenidap's cyclooxygenase (COX) inhibitory activity and the resulting pharmacological properties in experimental animals. Tenidap inhibited calcium ionophore-stimulated prostaglandin D2 synthesis by rat basophilic leukemia cells (COX-1) with an IC50 of 20 nM. In two different in vitro human test systems, tenidap inhibited COX-1 activity more potently than COX-2, although the relative potency ratio (COX-1/COX-2) differed markedly between the two systems. Tenidap inhibited the COX pathway when added to human blood in vitro (IC50, 7.8 μM) and when administered orally to monkeys, rats and dogs (at 5, 2.5 and 10 mg/kg p.o., respectively) and COX activity measured ex vivo in blood collected 2 to 4 hours post dose. After oral administration to rats, tenidap inhibited carrageenan-induced paw edema with an ED50 of 14 mg/kg and inhibited the glucocorticoid-resistant UV erythema in guinea pigs with an ED50 of 1.4 mg/kg. It retained antiinflammatory activity in adrenalectomized rats indicating that this property is independent of adrenal stimulation. Oral administration of tenidap inhibited the development of adjuvant-induced polyarthritis in the rat and exhibited antinociceptive activity in the murine phenylbenzoquinone and rat acetic acid abdominal constriction tests. These data indicate that tenidap is an effective antiinflammatory and analgesic agent in animal models. These cyclooxygenase-dependent pharmacologic activities do not explain tenidap's disease modifying anti-arthritic properties but add a useful symptom modifying component to its clinical profile.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Pharmacology, Biochemistry and Behavior 5 (1976), S. 583-586 
    ISSN: 0091-3057
    Keywords: Adjuvant arthritis ; Aspirin ; Drug discrimination ; Operant behavior
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Cardiovascular drug reviews 13 (1995), S. 0 
    ISSN: 1527-3466
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Inorganic and Nuclear Chemistry 33 (1971), S. 761-766 
    ISSN: 0022-1902
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 48 (1992), S. 214-215 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Advances in contraception 8 (1992), S. 81-88 
    ISSN: 1573-7195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Resumé Une récente immigrante de Roumanie a essayé de provoquer un avortement à la septième semaine de gestation en s'administrant par voie intra-utérine du sucrose hypertonique. L'avortement n'a pas été total et les saignements, l'infection et les résidus de la grossesse ont persisté pendant 13 semaines. La première évacuation par curetage utérin a été un échec mais le second curetage, effectué sous guidage sonographique en temps réel, a réussi. Il est rare en médecine moderne de se trouver face à des avortements auto-provoqués à l'aide de produits chimiques. Du fait cependant de la disparition du rideau de fer et d'immigrations massives, la fréquence des avortements auto-provoqués risque d'augmenter dans les pays occidentaux. Le traitement, le déroulement et l'aboutissement des avortements auto-provoqués différent quelque peu selon le cas type particulier; la distinction à faire réside donc entre les moyens chimiques et mécaniques et entre les différents agents utilisés pour les avortements induits par des produits chimiques. Il est préférable, pour les avortements provoqués à l'aide de moyens mécaniques, de les traiter 12 à 24 heures après une thérapie aux antibiotiques, alors que pour ceux qui ont été déclenchés chimiquement, il est indiqué de procéder au plus tôt à l'évacuation de l'utérus.
    Abstract: Resumen Una reciente inmigrante de Rumania intentó provocar un aborto a la séptima semana de gestación administrándose por vía intrauterina sucrosa hipertónica. El aborto no fue total y las pérdidas de sangre, la infección y los residuos persistieron durante 13 semanas. La primera evacuación por raspado uterino fracasó pero el segundo raspado, efectuado con guía sonográfica en tiempo real, tuvo éxito. En la medicina moderna es muy poco frecuente encontrarse con casos de aborto autoprovocado mediante sustancias químicas. Sin embargo, al desaparecer la Cortina de Hierro y surgir la inmigración masiva, puede aumentar en los países occidentales al frecuencia de los abortos autoprovocados. Dado que el tratamiento, desarrollo y resultado de los abortos autoprovocados son algo distintos, la distinciín pertinente ocurre entre los medios químicos y mecánicos y entre los diversos agentes utilizados para los abortos inducidos por sustancias químicas. En el caso de los abortos mecánicos, es preferible tratarlos de 12 a 24 horas después de una terapia con antibióticos y en el de los abortos químicamente inducidos, se recomienda proceder lo antes posible a la evacuación del útero.
    Notes: Abstract A new immigrant from Romania tried to induce abortion by intrauterine self-administration of hypertonic sucrose at 7 weeks' gestation. Complete abortion did not occur and bleeding, infection and pregnancy residua persisted for 13 weeks. Evacuation by uterine curettage had failed, but a second curettage under real-time sonographic guidance was successful. Self-induced chemical abortions are rarely encountered in modern medicine. However, elevation of the iron curtain and mass immigration may increase the frequency of self-induced abortions in Western countries. Since the management, course, and outcome of each type of self-induced abortion are somewhat different, the pertinent differentiation is between chemical and mechanical and between various agents used for chemical-induced abortions. Mechanical abortions are best treated 12 to 24 hours after antibiotic therapy, while in chemically-induced abortion early evacuation of the uterus is indicated.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 256 (1995), S. 159-161 
    ISSN: 1432-0711
    Keywords: Umbilical cord ; Fetal death ; Torsion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intrautrine fetal death was observed in a woman at 35 gestational weeks shortly after she was admitted to hospital due to suspected placental insufficiency expressed by oligohydramnios and fetal growth retardation. The pathologic examination showed umbilical cord torsion and an organized thrombus at the site of the torsion. This findings could imply that both the fetal death and the placental insufficiency were the results of the cord torsion.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 256 (1995), S. 159-161 
    ISSN: 1432-0711
    Keywords: Key words: Umbilical cord ; Fetal death ; Torsion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Intrautrine fetal death was observed in a woman at 35 gestational weeks shortly after she was admitted to hospital due to suspected placental insufficiency expressed by oligohydramnios and fetal growth retardation. The pathologic examination showed umbilical cord torsion and an organized thrombus at the site of the torsion. This findings could imply that both the fetal death and the placental insufficiency were the results of the cord torsion.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Protoplasma 66 (1968), S. 21-26 
    ISSN: 1615-6102
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary In the nuclei of atypical spermatids ofLumbricus terrestris granular or filamentous inclusions are surrounded by dense chromatin. Aggregation and condensation of chromatin in nuclei during spermatid differentiation coincide with increase in density, granularity, and the subsequent crystallization of the intranuclear inclusion. In mature spermatozoa, the crystalline inclusion displaying an irregular shape is composed of parallel repeating units measuring 50–80 Å. The subunits sometimes possess a clear central cavity. Atypical spermatozoa, possessing inclusions that distort their normally cylindrical shape, possess typical acrosomes, middle pieces, and flagella. Spermatozoa bearing intranuclear crystals are rarely observed in the seminal receptacles ofLumbricus. These intranuclear inclusions probably represent proteinaceous material that is not eliminated during nuclear differentiation. Their sole existence in the nuclei of spermatozoa, their transformation into crystalline structures during spermiogenesis, and their similarity to crystals in virus infected plant and animal cells suggest a viral origin.
    Type of Medium: Electronic Resource
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