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  • 1
    Electronic Resource
    Electronic Resource
    The relationship of glycaemic level to advanced glycation end-product (AGE) accumulation and retinal pathology in the spontaneous diabetic hamster (1998)
    Springer
    Diabetologia 41 (1998), S. 165-170 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Diabetic retinopathy ; chinese hamster ; advanced-glycation end-products ; pericytes.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To assess the relationship between glucose and advanced glycation end products (AGE) and the relationship between AGE and retinal changes in vivo, we studied the time course of retinopathy over 12 months in trypsin digest preparations and measured glycaemia and retinal AGE in spontaneous diabetic hamsters of mild (MD) and severe (SD) phenotypes. Blood glucose levels were elevated in MD (9.44 ± 0.76 mmol/l) and in SD (3 months: 24.3 ± 1.4 mmol/l; 12 months: 31.7 ± 0.8 mmol/l) over non-diabetic controls (NC: 7.15 ± 0.25 mmol/l; p 〈 0.05 or less vs MD; p 〈 0.001 vs SD). Similar relations were found for HbA1. Retinal AGE in mild diabetes was 405 ± 11.3 arbitrary units (AU) (NC 245 ± 7.7; p 〈 0.01) after 3 months and remained unchanged. A non-linear increase of AGE over time was found in severe hyperglycaemic hamsters (466 ± 21 AU after 3 months and 758 ± 21 AU after 12 months; p 〈 0.001 vs MD). Pericyte loss in mild diabetes progressed from –26 % after 3 months to –41 % after 12 months (p 〈 0.001 vs NC). Whereas the initial pericyte loss in severely diabetic hamsters was identical to the mildly diabetic group, a higher degree of pericyte loss occurred after 12 months (–57 %; p 〈 0.05 vs MD). Endothelial cell numbers remained unaffected by mild hyperglycaemia, but significantly increased over time in severe diabetes reaching 31.7 % above controls after 12 months (p 〈 0.001 vs NC and MD). Microaneurysms were absent in all retinae examined. Acellular capillary segments were increased in mild diabetes (3.83 ± 0.31 per mm2 of retinal area) and severe diabetes (7.83 ± 0.73) over controls (1.0 ± 0.23). These data suggest that a threshold of glycaemia might exist above which AGE removal systems become saturated. Pericyte loss and acellular capillary formation are associated with mild increases in blood glucose and AGE levels while endothelial cell proliferation requires higher glucose and AGE levels. [Diabetologia (1998) 41: 165–170]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050885
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Chronischer venöser Zugang über die Vena saphena Eine interessante Alternative im Falle des Vena-cava-superior-Syndroms (1999)
    Springer
    Der Chirurg 70 (1999), S. 1036-1040 
    Details
    ISSN: 1433-0385
    Keywords: Key words: Venous access ; Port-a-Cath ; Inferior vena cava ; Saphenous vein. ; Schlüsselwörter: Venöser Zugang ; Port-à-Cath ; V. cava inferior ; V. saphena.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Ein einfacher venöser Zugang beeinflusst die Lebensqualität der Patienten, die eine langfristige parenterale Therapie benötigen. Bei Kompression der V. cava superior wird der übliche Zugang über die V. subclavia oder jugularis schwierig, unmöglich oder ist gar kontraindiziert. Wir berichten über 7 Patienten, bei denen wir einen Katheter in die V. cava inferior über die V. saphena eingelegt haben. Alle zeigten eine Kontraindikation für die Implantation eines Port-à-Cath® als klassischen V.-cava-superior-Zugang (5mal V.-cava-superior-Kompressionssyndrom, einmal Tracheostomie, einmal ausgedehnter Thoraxwandtumor). Wir beschreiben die Operationstechnik und untersuchen die Indikationen, die Resultate und die Komplikationen dieser selten angewandten Technik.
    Notes: Summary. An easy venous access improves the quality of life of patients who need prolonged intravenous therapy. In the case of vena cava superior syndrome the classic access in the jugular or subclavian vein can be difficult or even impossible. We report on seven implantations of Port-a-Cath in the inferior vena cava for patients presenting contra-indications to classic venous access to the vena cava superior (five cases of vena cava superior compression syndrome, one tracheostomy and one extended tumor of thoracic wall). We describe the operative technique and we analyze the indications, the results and the complications of this rarely used technique.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001040050763
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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