ISSN:
1432-1130
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A novel poly(vinyl chloride) membrane electrode with dibutyl phthalate as plasticizer based on the pethidine-tetraphenylborate ion-association complex as ion-exchange site for the determination of pethidine hydrochloride in injections and tablets was developed. A linear response for 1 × 10–5 to 1 × 10–2 mol/L drug with a slope of 51.77 mV/decade was established. The optimum ¶pH range was 2–8. The lower detection limit was 2.18 × 10–6 mol/L. There were negligible interferences from a number of inorganic and organic cations and some common drug excipients. The electrode proposed had been successfully applied to determine pethidine hydrochloride in tablets and injections. The results correlated well with those obtained by the United States Pharmacopoeia standard procedure.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002160000463
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