ISSN:
1573-2568
Keywords:
PEPTIDE YY
;
NEUROPEPTIDE Y
;
INTESTINAL SECRETION
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Peptide YY (PYY) is a potent regulator ofintestinal secretion. These studies investigated therole of Y1 and Y2 receptor subtypes in mediating theantisecretory effects of PYY on mucosa-submucosapreparations of rat distal colon. Addition of vasoactiveintestinal peptide (VIP) to these tissues resulted in a140 ± 18% increase in basal short-circuit current(Isc) and the induction of Cl-secretion. VIP-stimulated increases in Isc were abolished bythe addition of each of PYY, (Pro34)-PYY, aY1 receptor-selective agonist, and PYY-(3-36), anendogenous Y2 receptor-selective ligand. However, whentissue neural transmission was blocked with tetrodotoxin, neither PYY norits receptor subtype-selective analogs were able toinhibit VIP-stimulated increases in Isc.These results suggest that in the rat distal colon, thesc antisecretory actions of PYY are mediated through acombination of Y1 and Y2 receptor subtypes or through anovel receptor subtype that is unable to discriminatebetween (Pro34)-PYY and PYY-(3-36).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1018869116284
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