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  • 1
    Electronic Resource
    Electronic Resource
    EFFECT OF DIETARY SODIUM CHLORIDE ON THE DEVELOPMENT OF RENAL GLOMERULAR AND VASCULAR LESIONS IN HYPERTENSIVE RATS (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 20 (1993), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 〈list xml:id="l1" style="custom"〉1The hypothesis that high levels of NaCl in the diet aggravates hypertension-associated renal vascular lesions was examined in unilaterally nephrectomized deoxycorticosterone acetate treated (DOCA) and two kidney one clip (2K1C) hypertensive rats, as well as normotensive controls.2High NaCl diet significantly increased systolic blood pressure (SBP) in DOCA rats, but had little effect on SBP in normal control rats, and did not affect the rise of SBP in 2K1C rats.3High NaCl diet was associated with a higher percentage of glomerular lesions and renal arterial and arteriolar lesions in DOCA and 2K1C rats (P〈0.05).4Thus high NaCl intake exacerbated renal arterial and arteriolar and glomerular lesions in both DOCA and 2KlC hypertensive rats. In 2K1C rats this effect may be in part independent of blood pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1993.tb03014.x
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  • 2
    Electronic Resource
    Electronic Resource
    COMPARISON OF THE VASCULAR AND GLOMERULAR CHANGES IN AORTIC-LIGATURE AND DOCA-SALT HYPERTENSION (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 16 (1989), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Animals and histology from two previous investigations were used to test the hypothesis that a similar elevation in blood pressure may result in a different sequence of pathological changes in different experimental models of hypertension, DOCA-salt and aortic-ligature hypertension.2. To assess differences in morphological parameters, individual animals in the two groups were paired (n= 12) for the same level of blood pressure at sacrifice.3. Vascular damage was significantly less in the DOCA-salt group (P 〈 0.01). Glomerular lesions however were more severe in the DOCA-salt group. In rats with aortic-ligature hypertension significantly fewer glomeruli had fibrinoid and/or crescents than in DOCA-salt rats (P 〈 0.001). There were fewer glomeruli with epithelial cell droplets (ECD) and fewer ECD per glomerulus in aortic-ligature when compared with DOCA-salt hypertension (P 〈 0.001, P 〈 0.001, respectively).4. This study highlights the significance of factors other than blood pressure per se in producing vessel and glomerular lesions in experimental hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1989.tb01615.x
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  • 3
    Electronic Resource
    Electronic Resource
    INFLUENCE OF SOMATOSTATIN ANALOGUE (SMS 201–995, OCTREOTIDE) ON BLOOD PRESSURE IN ADRENOCORTICOTROPHIN (ACTH) TREATED RATS: ROLE OF HYPERINSULINAEMIA IN ACTH HYPERTENSION (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 20 (1993), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The hypothesis that adrenocorticotrophin (ACTH)-induced hypertension is a consequence of steroid-induced hyperinsulinaemia was tested using the somatostatin analogue (sandostatin, octreotide) to inhibit insulin release in Sprague-Dawley (SD) rats (n= 41).2. Octreotide (20 μg, twice daily) did not modify blood pressure, plasma glucose, bodyweight, water and electrolyte balance, or organ weights but inhibited insulin secretion in the SD rat.3. Compared with sham injection, ACTH-treated (0.5 mg/kg per day) SD rats showed an increase in blood pressure (sham 111 ± 4 mmHg; ACTH 140 ± 5 mmHg on treatment day 10 (P≤ 0.01), organ weights, water intake, urine volume, plasma glucose, insulin and sodium concentrations, and decrease of bodyweight and plasma potassium concentration.4. Systolic blood pressure in rats treated with combined octreotide and ACTH was similar to that in rats on ACTH alone. Plasma insulin concentration was lower in octreotide + ACTH treated rats than with ACTH treatment alone. There were no differences in body or organ weights, plasma glucose, water or electrolyte balance.5. Octreotide lowered plasma insulin concentration to the normal range but did not modify ACTH-induced hypertension in SD rats. These data do not support the notion that insulin-mediated alterations in blood pressure are a major mechanism for ACTH-induced hypertension in the rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1993.tb01647.x
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  • 4
    Electronic Resource
    Electronic Resource
    ACUTE HORMONAL AND RENAL EFFECTS OF ORAL DILEVALOL IN NORMAL MEN (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 16 (1989), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Acute hormonal and renal effects of dilevalol (200 mg), a non-selective β-blocking drug with vasodilator properties, were compared with placebo in six normal men on constant sodium intake.2. Control and treatment blood pressures were lower with dilevalol than placebo, although the pattern of blood pressure fall was similar in both.3. Plasma active renin and aldosterone concentrations were lower on dilevalol than placebo after 4 h of recumbency (P 〈 0.05).4. Total plasma renin, renin substrate, cortisol and atrial natriuretic peptide concentrations were similar on dilevalol and placebo.5. There were no differences in glomerular filtration rate and no deleterious biochemical or haematological changes on dilevalol or placebo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1989.tb01909.x
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  • 5
    Electronic Resource
    Electronic Resource
    EFFECTS OF INDOMETHACIN ON STEROID-INDUCED CHANGES IN PRESSOR RESPONSIVENESS IN MAN (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 15 (1988), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. It has been shown previously that hydrocortisone (F) increases pressor responsiveness in normal subjects. The present study examined the role of vasodilator prostanoids in determining these changes.2. Pressor responsiveness to angiotensin II (AII) (1–8 ng/kg per min) and phenylephrine (PE) (0.3–0.9 μg/kg per min) was examined in six normal men receiving: no treatment (day 1); 100 mg indomethacm p.o. (INDO) in three divided doses over 20 h (day 2); 200 mg F for 5 days, 50 mg 6 hourly p.o. (day 6); F plus 100 mg INDO (day 7).3. Blood pressure, body weight and plasma glucose rose with F and plasma potassium fell. F alone produced significant increases in response to AII at 2 ng/kg per min, for systolic pressure (SBP), diastolic pressure (DBP) and mean arterial pressure (MAP), and at 1 ng/kg per min for DBP. The threshold for SBP, DBP and MAP rises with AII was decreased by F. Responses to PE following F were greater at 0.6 μg/kg per min for SBP, DBP and MAP and the threshold for all parameters fell.4. INDO alone had no significant blood pressure or metabolic effects and no effect on the magnitude of the blood pressure rise with AII, but decreased the threshold dose for effects on MAP. INDO had no effect on the magnitude of the pressure rise with PE, but decreased the threshold dose for effects on SBP.5. INDO did not modify responsiveness or threshold to AII following F. Responsiveness to PE was unchanged and threshold fell for SBP only during INDO.6. These data do not suggest a major role for vasodilator prostanoids in modifying pressor responsiveness in F-treated subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1988.tb01078.x
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  • 6
    Electronic Resource
    Electronic Resource
    ANGIOTENSIN CONVERTING ENZYME INHIBITION DOES NOT PREVENT DEVELOPMENT OF ACTH-INDUCED HYPERTENSION IN SHEEP (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 12 (1985), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The role of the renin-angiotensin system in the onset of ACTH-induced hypertension was examined in five conscious sheep.2. Captopril infusion alone (15 μg/kg per day) for 2 days produced a small fall in blood pressure.3. After 2 days of captopril ACTH was infused (20 μg/kg per day) for 3 days together with captopril. The blood pressure and electrolyte effects of ACTH administration were not modified by captopril pretreatment.4. These experiments establish that angiotensin II is not important in the onset of ACTH-induced hypertension in sheep.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1985.tb02321.x
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  • 7
    Electronic Resource
    Electronic Resource
    EFFECT OF POTASSIUM LOADING ON BONE SODIUM AND TOTAL EXCHANGEABLE SODIUM IN SHEEP (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 15 (1988), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effect of potassium (K) loading for 10 days on bone sodium (Na) and total exchangeable Na in sheep was examined.2. There were no significant changes in Na space or exchangeable Na after K loading.3. Bone Na concentration decreased by approximately 20% after K loading.4. The degree of mobilization of Na from both the non-exchangeable and exchangeable pools in bone is sufficient to account to a large degree for the observed increase in extracellular fluid volume and the net negative sodium balance which is observed during K loading.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1988.tb01018.x
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  • 8
    Electronic Resource
    Electronic Resource
    EFFECT OF ACTH ADMINISTRATION ON URINARY KALLIKREIN EXCRETION IN MAN (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 11 (1984), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effect of ACTH administration on urinary kallikrein excretion and its relationship to changes in plasma and urine electrolytes, renin concentration and steroids was examined in normotensive and mildly hypertensive subjects.2. ACTH administration produced hypokalaemia, initial urinary sodium retention, a fall in active plasma renin concentration, a transient rise in plasma aldosterone concentration and sustained rises in plasma deoxycorticosterone concentration and urinary kallikrein activity.3. Changes in patients with mild hypertension were similar in pattern to normotensives, but urinary kallikrein concentrations were lower.4. The effects of ACTH on urinary kallikrein excretion appeared to be independent of aldosterone and correlated most closely with deoxycorticosterone concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1984.tb00243.x
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  • 9
    Electronic Resource
    Electronic Resource
    EFFECT OF POSTASSIUM, ANGIOTENSIN II AND ACTH ON BLOOD ALDOSTERONE AND CORTISOL IN SHEEP ON DIFFERENT DIETARY POTASSIUM AND SODIUM INTAKES (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 11 (1984), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The short term aldosterone response to manipulations of potassium (K), angiotensin II (AII) and ACTH were examined in sheep on a variety of chronic electrolyte regimes.2. Reduction in Na intake increased blood aldosterone to a greater extent on 100 mmol/day K than a K-free diet.3. Aldosterone increased in response to AII under conditions of chronic dietary Na restriction, in contrast to acute Na depletion.4. The effects of K, AII, and ACTH on aldosterone concentrations in sheep on varying intakes of Na and K are similar to that reported for other species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1984.tb00245.x
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  • 10
    Electronic Resource
    Electronic Resource
    ACTIVE AND INACTIVE RENIN IN CRITICALLY ILL PATIENTS (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 12 (1985), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The relationship between active (A) and inactive (I) plasma renin concentrations (PRC) was examined in critically ill patients to test for intravascular renin activation in states of shock and tissue damage.2. Critically ill patients had significantly elevated APRC and lowered IPRC:APRC ratio compared with age and sex matched healthy subjects. IPRC in the critically ill was similar to the control group.3. During blood donation normal volunteers showed a twofold increase in APRC. The rise in APRC was proportionately greater than for IPRC, with a subsequent fall in IPRCAPRC ratio.4. In both critically ill patients and blood donors elevated APRC was associated with decreased IPRC:APRC ratio, consistent with either consumption of the inactive renin zymogen or preferential secretion of the active form. Individual critically ill patients displayed markedly depressed ratios but with only moderately elevated APRC, a pattern suggestive of intravascular renin activation. Consistent evidence for intravascular or extravascular activation of renin was not apparent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1985.tb00914.x
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