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  • 1
    Electronic Resource
    Electronic Resource
    Epidermoid tumor of unusual expansion at the skull base (1987)
    Springer
    Neurosurgical review 10 (1987), S. 299-303 
    Details
    ISSN: 1437-2320
    Keywords: Brain base processes ; epidermoid tumor ; neuroimaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The case of an epidermoid tumor of unusual extension at the skull base is reported. Various and comprehensive radiologic examinations are described and the difficulty of diagnosis of rare brain-base prosesses is shown. Although neuroimaging with CT scan, CT cisternography, angiography and MRI was carried out on adequate diagnosis could not be made so that the question of operability could not be answered. In this case MRI did not prove to be more sensitive than other traditional radiologic examinations for the primary diagnosis, postoperative control, or clarification of suspected recurrence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01781955
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Intracranial Inflammatory Tumors: A Survey of their Various Etiologies by Presentation of 5 Cases (1999)
    Springer
    Journal of neuro-oncology 43 (1999), S. 209-217 
    Details
    ISSN: 1573-7373
    Keywords: inflammatory pseudotumor ; cerebral vasculitis ; Rosai–Dorfman-disease ; intracranial pachymeningitis ; cerebral lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Due to similar clinical and neuroradiological features, intracranial inflammatory tumors (IITs) are frequently mis-diagnosed as brain neoplasms, from which they notably differ in respect to therapy and prognosis. In this article, five cases of such tumors are presented. Three of the patients with brain tumors (cases 3, 4 and 5) presented a history of ‘pararheumatic’ syndromes but no diagnosis of defined immunopathies. On the basis of radiological findings, all processes were classified as genuine brain neoplasms, but histology showed reactive inflammatory features. The possible etiologies of these ‘tumors’ are discussed on the basis of all clinical and histological data of the patients. The spectrum of diseases potentially leading to the manifestation of an IIT is reviewed. Additionally, the presentation of case 5, who developed a highly malignant B-cell-lymphoma 6 months after the removal of an IIT without any histological signs of atypia, shows that this differential diagnosis always has to be kept in mind.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006294117031
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Distinct Radiochemotherapy Protocols Differentially Influence Cellular Proliferation and Expression of p53 and Bcl-2 in Glioblastoma Multiforme Relapses In Vivo (2000)
    Springer
    Journal of neuro-oncology 48 (2000), S. 121-129 
    Details
    ISSN: 1573-7373
    Keywords: apoptosis ; proliferation ; p53 ; Bcl-2 ; transglutaminase ; immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Several protocols for the adjuvant treatment of glioblastoma multiforme (GBM) are currently being evaluated. In this context, little is known about the influence of radiochemotherapy on apoptosis and the expression of apoptosis-related proteins in vivo. We have analyzed the incidence of apoptosis using in situ nick translation (ISNT) and expression of Ki-67 (MIB-1), p53 (DO-1 and DO-7), Bcl-2 and transglutaminase II (TGase II) by immunohistochemistry in 41 patients with GBM and their matched relapses. Sixteen patients received radiochemotherapy, 18 irradiation and 7 no treatment. Radiochemotherapy resulted in an increase in Bcl-2+ cells (p=0.013). Irradiation caused the reduction of MIB-1+ (p=0.0015), DO-7+ (p=0.0043) and the increase of Bcl-2+ cells (p=0.016). We calculated a positive correlation between high TGase II scores in patients preceding radiochemotherapy (p=0.0186) and no treatment (p=0.0158), low ISNT scores (p=0.0018) and high DO-1 scores (p=0.0233) in patients preceding irradiation and short time to progression. These data show that distinct postsurgical radiochemotherapy protocols differentially alter cellular proliferation and expression of p53 and Bcl-2 in GBM relapses. Furthermore, we show that ISNT, DO-1 and TGase II labeling scores are therapy-specific predictors of time to progression in GBM patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006462618800
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    Paper (German National Licenses)
    Fulltext
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