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  • 1
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 45 (1989), S. 647-650 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 46 (1990), S. 2115-2117 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 49 (1993), S. 246-250 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of radioanalytical and nuclear chemistry 98 (1986), S. 371-380 
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The cyclotron production of21Na, via the20Ne(d, n)21Na and the20Ne(3He, pn)21Na and20Ne(3He, 2n)21Mg →21Na nuclear reactions, has been investigated. Transfer of21Na from the production target to the medical application site some 10 m distant was achieved by gas phase and liquid phase systems, both of which are described. Under optimal conditions 111 MBq·ml−1 (3 mCi·ml−1) of21Na were available at the dispensing reservoir 10 m distant from the production target, when irradiating with a 5 μA deuteron beam current. Incident deuteron energy was degraded to below 3.0 MeV by a 350 μm Al entrance foil, to avoid production of18F. The charge distribution of21Na inside the production target and inside the gas phase transfer tube at distances of 1 m and 15 m were determined, and are reported along with data from similar studies during18F production via the20Ne(d, α)18F reaction.21Na accumulated primarily at the cathode, indicating the production of positively charged species, whereas18F was equally distributed between the electrodes in a production target constructed especially for measuring the charge distribution of the radioactive species.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1619-7089
    Keywords: Iodine-123 iodoazomycinarabinoside ; Hypoxia ; Diabetes mellitus ; Peripheral vascular disease ; Radionuclide imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Peripheral vascular disease is a serious and common complication in patients with diabetes mellitus (DM). Evaluation is, conventionally, by transcutaneous oxygen tension measurements (TcpO2), although this technique has some limitations in the evaluation of tissue viability. We have evaluated a new, radiolabelled, in vivo marker of tissue hypoxia, iodoazomycinarabino-side (IAZA), by comparing TcpO2 measurements with patterns of iodine-123 IAZA uptake in ten patients (19 lower limbs) with DM and peripheral vascular disease using conventional gamma camera imaging techniques. Normal uptake patterns were seen in limbs in which normal TcpO2 measurements were obtained. Diffusely increased uptake of [123I]IAZA was seen in limbs with reduced TcpO2 Focally increased uptake was seen in ulcers or in areas of atrophic skin change. A semiquantitative measure showed an inverse correlation between [123I]IAZA and TcpO2 values. These data suggest that tissue hypoxia can be imaged in this population of patients and that severity of disease can be assessed. A longitudinal prospective trial is now being developed.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1619-7089
    Keywords: Iodoazomycin arabinoside ; Hexamethylpropylene amine oxime ; Hypoxia ; Penumbra ; Stroke
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Current routine clinical techniques, including angiography and perfusional single-photon emission tomography, can be used to indicate problems in cerebral vascular supply and areas of cerebral hypoperfusion following a stroke, but cannot distinguish between ischaemic core and penumbra. In order to image specifically the penumbra, a method or indicator should be able to define areas with reduced blood flow, and a degree of metabolic compromise. In this context, the tissue could be regarded as hypoxic rather than ischaemic, and we have therefore chosen to investigate the potential of radio-labelled hypoxic markers in the study of ischaemia. In order to combine a hypoxic marker with a blood flow marker we used technetium-99m hexamethylpropylene amine oxime (99mTc-HMPAO) and iodine-125 iodoazomycin arabinoside (125I-IAZA), during cerebral ischaemia in the rat middle cerebral artery occlusion model.99mTc-HMPAO and125I-IAZA were injected simultaneously 2 h following occlusion of the middle cerebral artery, and 5 h before decapitation. Paired autoradiograms were produced and compared. Three distinct patterns emerged from the autoradiograms: slightly decreased perfusion with no uptake of the hypoxic marker indicating an area of misery perfusion; moderately decreased perfusion with concomitant uptake of iodoazomycin arabinoside, a region of hypoxia; and severely decreased perfusion with no retention of the hypoxic tracer. In conclusion, we present a new use for an imaging agent in the investigation of cerebral hypoxia. This agent, IAZA together with HMPAO, provides a means of separating the penumbra into regions of misery perfusion and hypoxia. The potential impact of this may be important in the clinical investigation of stroke.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 4 (1979), S. 199-201 
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The chronic uremic condition was induced in male Wistar rats by long term maintenance of the animals following sequential sub-total and contralateral nephrectomies. Hepatic reticuloendothelial (RES) activity was estimated by non-invasive measurement of blood clearance rates and hepatic uptake of99Tcm sulfur colloid administered intravenously. The blood half-time, and the blood clearance rate constants for normals and chronic uremics were 78±10 s and 49.5±5 s, and 7.51±1.04×10−3 s−1 and 10.81±1.17×10−3 s−1 respectively. The normal hepatic uptake rate constant was 9.03±1.25×10−3 s−1, compared with a uremic uptake rate constant of 14.34±1.51 s−1. Measurement of total liver radioactivity upon termination, 15 min after injection, showed significantly increased total uptake in uremia, whereas no change in spleen radioactivity was observed. The clinical implications of these data are discussed.
    Type of Medium: Electronic Resource
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