ISSN:
1075-2617
Keywords:
Lactoferrin
;
peptide immunosuppressors
;
thymopentin analogues
;
Chemistry
;
Biochemistry and Biotechnology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
It has been found that the disulphide-bridged 231-245 pentadecapeptide loop of the lactoferrin (LF) N-lobe contains a region of immunosuppressive activity. The activity resides within a thymopentin-like sequence (Arg-Lys-Pro-Val-Asp) of the loop. Peptides related to the 575-589 loop of the LF C-lobe differ in their immunomodulatory activity from those related to the 231-245 loop. We ascribe this difference to the replacement of the Asp residue in the 231-245 loop by Thr in the 575-589 loop. Two other fragments of LF which were studied, 27-34 and 309-315, do not manifest any activy in the DTH test (cellular immune response), but, on testing in vivo, stimulate the humoral immune response. The 27-34 fragment is related to the bactericidal and immunostimulative region of LF identified by Bellamy et al. [1]. Our results show that the LF molecule contains, not only the known immunostimulating mini-domain, but also a region endowed with immunosuppressive activity.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/psc.310010504
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