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  • 1
    Electronic Resource
    Electronic Resource
    P53 accumulation and proliferating-cell nuclear antigen expression in human lung cancer (1995)
    Springer
    Journal of cancer research and clinical oncology 121 (1995), S. 371-377 
    Details
    ISSN: 1432-1335
    Keywords: p53 ; Lung cancer ; Tumor-suppressor gene ; PCNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mutations in thep53 gene are currently the commonest genetic alterations in human malignant tumors, including non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). Alterations of the protein induced by gene mutations enables the mutant protein to become more stable, resulting in the accumulation of P53 in quantities detectable by immunohistochemistry. Although previous studies document the accumulation of P53 in lung cancer, there is little information regarding the usual frequency of accumulation based on a comprehensive number of lung tumors. A total of 328 paraffin-embedded lung carcinoma specimens were analyzed for P53 accumulation and for the expression of the proliferating-cell nuclear antigen (PCNA) by standard immunohistochemistry. Among 49 SCLC, 35% were positive for p53 and 51% were positive for PCNA. Out of 279 NSCLC, 43% showed a positive P53 immunoreaction and 72% displayed detectable amounts of PCNA. In squamous-cell carcinomas a statistically significant increased accumulation of P53 was found compared to adenocarcinomas (P=0.001). Among the 233 PCNA-positive tumors the relative number of P53-positive specimens was higher compared to the total number of tumors. Since immunohistochemical investigations should contribute to the improvement of the clinical diagnosis and treatment or give information on the prognosis, we conclude from our results that it seems to be legitimate to assess the P53 status exclusively in the specimens positive for PCNA. Immunohistochemical investigations under consideration of the PCNA status yielded good and fast recognition ofp53 mutations leading to intracellular P53 protein accumulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01225691
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  • 2
    Electronic Resource
    Electronic Resource
    Pathology of small-cell lung cancer (2000)
    Springer
    Journal of cancer research and clinical oncology 126 (2000), S. 361-368 
    Details
    ISSN: 1432-1335
    Keywords: Key words Small-cell lung cancer ; Combined small-cell carcinoma ; Neuroendocrine lung tumors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The morphological differentiation between small-cell and non-small-cell lung cancer has great prognostic and therapeutic significance for the patient. Malignant lung tumors are now classified according to the new 1999 WHO/IASLC classification of lung and pleural tumors. The variant of heterogeneously differentiated “combined small-cell carcinoma” can be distinguished from classical small-cell carcinoma, whereas the subtype of “intermediate cell carcinoma” is no longer used. Together with “large-cell neuroendocrine carcinomas” and typical or atypical carcinoid tumors, small-cell lung cancers are currently histogenetically categorized as neuroendocrine lung tumors. In contrast to large-cell neuroendocrine carcinoma, the immunohistochemical demonstration of neuroendocrine differentiation is not a prerequisite for the diagnosis of small-cell lung cancer. Although electron-microscopical, immunohistochemical, and molecular-biological findings have considerably increased our understanding of the pathogenesis and progression of malignant lung tumors, routine pathological-anatomical diagnostics are still decisively based on light-microscopical evaluation of tissue samples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00008483
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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