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  • 1
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] To identify differentially expressed genes in infiltrating ductal carcinoma (IDC) of the breast, we measured the gene expression profiles of 15 IDC and 13 normal human breast tissues, using the Affymetrix GeneChip array platform for simultaneous analysis of over 60,000 genes. Fold-change comparison ...
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 31 (1973), S. 63-76 
    ISSN: 1432-2072
    Keywords: Fenfluramine ; Anorexia ; Activity Analysis ; C.N.S. Stimulation ; Stereotyped Behaviour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two experiments were conducted on the effects of chronic administration of fenfluramine on behaviour and body weight in rats. In Experiment One the effects of 28 day chronic administration were studied. A dose related rapid weight loss was observed in treated subjects, with development of tolerance to the effects of the drug on body weight after 14 days administration. Observations of behaviour were made on days 1, 14 and 28 of chronic administration according to a “time sampling” procedure of behavioural categorisation. The incidence of some behavioural patterns varied significantly between observation days, although observations of control subjects were never significantly different. By the 28th day of administration tolerance to the behavioural effects of the drug had developed, no dose/response eifects being noted in contrast to the results for prior observation days. In Experiment Two confirmation of the development of behavioural tolerance was obtained. Abnormal, “stereotyped” behaviour induced by a very high dose of fenfluramine showed a much lower incidence in subjects that hadr eceived fenfluramine for 30 days than in saline controls. Attention is drawn to the difficulties inherent in describing psychotropic agents as either sedatives or stimulants. It is suggested that although fenfluramine is generally considered to be a sedative, stimulant effects may be observed after chronic administration of anorexic doses. Similarities between the effects of high doses of fenfluramine and amphetamine are described.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    The journal of occupational rehabilitation 8 (1998), S. 47-60 
    ISSN: 1573-3688
    Keywords: cognitive ; behavioral ; physiotherapy ; goal setting ; work ; functional retraining
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract For chronic pain sufferers, the path back to work or to other productive activity can be a long and complex one of overcoming both physical and psychological obstacles. These obstacles can be effectively addressed, and patients enabled to return to their previous activities and to achieve valued goals, by pain management. The major practical components of this are physical retraining, steady increase in range and extent of abandoned and novel activities, and adoption of a realistic model of pain and of its impact on lifestyle. The entire program is underpinned by behavioral and cognitive principles, and these are also used directly to reduce unhelpful beliefs and distress. These components must be integrated, or progress from work in any one area is limited by lack of change in others. This paper describes activities retraining using pain management, based on the work of INPUT, a London-based unit.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of behavioral medicine 23 (2000), S. 367-376 
    ISSN: 1573-3521
    Keywords: optimistic bias ; Health Belief Model ; breast cancer ; prostate cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract Why do people fail to engage in positive behaviors which will promote their health and well-being? Researchers addressing this question adopt primarily one of two perspectives, drawing either on theories of health behavior, such as the Health Belief Model (HBM), or on theories of risk perception, such as unrealistic optimism. To overcome this compartmentalization, two studies of cancer screening behavior assessed the extent to which unrealistic optimism occurred in relation to each of the elements of the HBM: severity and curability of cancer and the benefits of, and barriers to, having a screening test. Data were collected using telephone interviews, dialing numbers randomly selected from the telephone directory. In the first study 164 women aged 50 to 70 years responded to questions about breast cancer and screening mammography, while in the second study 200 men aged 45 to 60 years responded to questions about prostate cancer and screening using the prostate specific antigen test. Women had an optimistic bias in relation to breast cancer risk and severity and barriers to having a screening mammogram but not in relation to the benefits of screening. For prostate cancer, there was an optimistic bias for all HBM variables: risk and severity of prostate cancer and barriers to and benefits of screening. It was concluded that unrealistic optimism is broader than perceived risk, being evident for all elements of the HBM.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1615-5742
    Keywords: Key words: cytomegalovirus, colitis, enteritis, human immunodeficiency virus, infants, leiomyolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report two infants with the acquired immunodeficiency syndrome (AIDS) and rectal bleeding due to cytomegalovirus (CMV) ileitis and colitis with minimal focal mucosal ulceration but with extensive leiomyolysis of the muscularis propria. Immunostaining and in situ hybridization for CMV showed numerous viral inclusions in the myocytes of the muscularis propria and vascular endothelium/smooth muscle with only occasional inclusions present in the muscularis mucosae. Colectomy was curative in one patient; in the other the bowel was only examined at postmortem.
    Type of Medium: Electronic Resource
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