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  • 1
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. A prospective controlled study investigated the effects of oral contraceptives on blood pressure in 485 women who were between 17 and 46 years of age and had blood pressures of 〈140/90 mmHg at entry. The women were divided into seven groups depending on the chosen method of contraception: intrauterine device or barrier method (control group); ethinyl oestradiol 30 μg plus levonorgestrel 150 μg (Microgynon-30 or Ovranette); norethisterone 350 μg (Micronor); norgestrel 75 μg (Neogest); norethisterone oenanthate 200 mg intramuscularly every 2 months for the first 6 months, then every 3 months thereafter; ethinyl oestradiol 30 μg plus ethynodiol diacetate 2 mg (Conova-30); and ethynodiol diacetate 500 μg (Femulen). Blood pressures were measured every 3 months by the family planning clinic nurse under standardized conditions using an Elag-Köln automatic sphygmomanometer. After one year, blood pressure had risen significantly (P〈0.05) in the 137 women taking ethinyl oestradiol plus levonorgestrel (mean systolic and diastolic rises 6.4 and 2.7 mmHg respectively) and in the 91 women taking ethinyl oestradiol plus ethynodiol diacetate (mean systolic and diastolic rises 6.2 and 3.0 mmHg respectively). The 94 women taking the progestogen-only preparations and the 143 women in the control group showed no increases in blood pressure. These data were confirmed after 2 years of follow-up.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 59 (2004), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cardiac output may be an important determinant of the induction dose of intravenous anaesthetic. Esmolol is known to reduce cardiac output, and we examined its effect on the propofol dose required for induction of anaesthesia. The size of the effect seen with esmolol was compared with midazolam co-induction. Sixty patients were randomly allocated to placebo (saline), esmolol (1mg.kg−1 bolus, followed by an infusion at 250 µg.kg−1min−1) or midazolam (0.04 mg.kg−1) groups. Induction of anaesthesia commenced 3 min following the administration of the study drug, using a Diprifusor set to achieve plasma propofol concentrations of 10 µg.ml−1 at 5 min. The primary end point used was the propofol dose per kg at loss of response to command. The mean (SD) propofol dose for each group was 2.38 (0.48) mg.kg−1 for placebo, 1.79 (0.36) mg.kg−1 for esmolol and 1.34 (0.35) mg.kg−1 for midazolam (all means significantly different; p 〈 0.0005). We found that predosing with esmolol reduces the propofol requirements for induction of anaesthesia by 25%.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Applied composite materials 6 (1999), S. 251-267 
    ISSN: 1573-4897
    Keywords: composite ; fatigue ; repair ; stress analysis ; structural testing ; validation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract This paper presents the results obtained to date as part of a comprehensive repair-substantiation program currently in progress for a safety-critical repair to an F-111 lower wing skin. From the viewpoint of demonstrating compliance with certification requirements, this F-111 repair represents the most technically challenging bonded repair undertaken to date by the RAAF. It is particularly significant that the repair was designed and implemented entirely by RAAF personnel, on the basis of design principles and application procedures developed by DSTO. This constitutes an important milestone in technology transfer from DSTO to the RAAF. The repair substantiation involves both detailed finite element (FE) stress analyses and structural testing at three levels, ranging from coupon-size specimens (representative bonded joints) to quasi- full-scale specimens representing a spar-stiffened wing-box structure. The close coupling of analysis and testing is shown to lead to a time- and cost-efficient certification package, with a confidence level comparable with full-scale structural testing.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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