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  • 1
    Electronic Resource
    Electronic Resource
    RELATION BETWEEN ATRIAL AND VENTRICULAR ANTI-ARRHYTHMIC ASSAY METHODS: RATIONALE FOR A SCREENING PROGRAM (1956)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 64 (1956), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1956.tb36830.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Muscarinic Action of Murexine and Some Related Choline Esters (1957)
    [s.l.] : Nature Publishing Group
    Nature 180 (1957), S. 988-989 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A series of five dogs was anaesthetized with sodium pentothal followed by oc-chloralose. The femoral arterial flow-rate was measured with a rotameter placed in series between the central and peripheral ends of the artery. Blood pressure was recorded simultaneously with a pressure transducer. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/180988a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A Non-diuretic Benzothiadiazine with Anti-hypertensive Properties (1961)
    [s.l.] : Nature Publishing Group
    Nature 192 (1961), S. 176-177 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Accordingly, several types of benzothiadiazine analogues were synthesized by Dr. J. G. Topliss, M. H. Sherlock and Dr. N. Sperber of the Chemical Research Division, Schering Corporation, and afterwards evaluated for anti-hypertensive and diuretic activities. It soon became apparent that certain ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/192176a0
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Pentaerythritol trinitrate and glyceryl trinitrate on intramyocardial oxygenation and perfusion in the dog. Krogh analysis of transmural metabolism (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 2 (1975), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effect of intravenous pentaerythritol trinitrate and glyceryl trinitrate on left ventricular subepicardial (epi) and subendocardial (endo) Po2 and perfusion were compared in anaesthetized open-chest mongrel dogs. Tissue Po2 was determined simultaneously at a depth of 3 mm (epicardial) and 9 mm (endocardial) with small platinum electrodes by polarography. In a separate series of dogs tissue perfusion of those regions was measured by hydrogen (H2) clearance using similar electrodes.2. Both nitrates increased endocardial Po2 while epicardial Po2 was not altered. Perfusion was determined at the point of the maximal rise in endocardial Po2 (4–7 min after injection of either nitrate). At that period average coronary artery inflow and epicardial perfusion were decreased but endocardial perfusion was not significantly altered.3. Using the data on Po2, hydrogen clearance and intercapillary distance, the effect of the nitrates on transmural metabolism (oxygen consumption) was estimated by Krogh analysis. Basal endocardial metabolism was 20–30% higher than epicardial metabolism. The nitrates reduced metabolism in each region. The absolute decrease in oxygen consumption was greater in the endocardium.4. The results show that both pentaerythritol trinitrate and glyceryl trinitrate improve endocardial oxygenation by producing a more favourable balance between perfusion and oxygen requirements in that region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1975.tb01858.x
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  • 5
    Electronic Resource
    Electronic Resource
    Pentaerythritol trinitrate and glyceryl trinitrate on myocardial oxygen consumption and haemodynamics in the dog (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 2 (1975), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of pentaerythritol trinitrate (pentrinitrol) and glyceryl trinitrate on myocardial oxygen consumption and myocardial and systemic haemodynamics were studied in anaesthetized open-chest dogs. An in vivo oximeter in the coronary sinus permitted continuous determination of arteriovenous oxygen difference and myocardial oxygen consumption. All parameters were determined simultaneously at various intervals after drug administration.2. Myocardial oxygen consumption was diminished by both nitrates for more than 16 min. Changes in arteriovenous oxygen difference and coronary sinus oxygen content were variable between drugs. Following an initial transient increase, coronary blood flow was reduced by both nitrates. Aortic blood pressure, aortic blood flow, left ventricular end-diastolic pressure and left ventricular dP/dt were also reduced. Heart rate and contractile force were not appreciably altered by either nitrate.3. The decrease in myocardial oxygen consumption appears to be associated with the haemodynamic profile of these drugs. Both nitrates produced comparable reductions in preload (left ventricular end-diastolic pressure) and afterload (aortic pressure) as well as dP/dt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1975.tb01857.x
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  • 6
    Electronic Resource
    Electronic Resource
    Pimobendan (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Cardiovascular drug reviews 6 (1988), S. 0 
    Details
    ISSN: 1527-3466
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1527-3466.1988.tb00380.x
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  • 7
    Electronic Resource
    Electronic Resource
    A Potent New Benzothiadiazine Diuretic (1960)
    [s.l.] : Nature Publishing Group
    Nature 187 (1960), S. 603-604 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In an effort to determine how further structural modifications of the chlorothiazide nucleus might alter the renal actions, we have undertaken an investigation of derivatives substituted in the 3 position of the dihydro analogue7. This is a preliminary report of pharmacological studies on one of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/187603a0
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    Paper (German National Licenses)
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