ISSN:
1432-0428
Keywords:
Non-enzymatic protein glycosylation
;
protein glycation
;
quantitation
;
reductive properties
;
fructosamine test
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Repeated estimation of plasma protein glycation by the fructosamine assay gave more variable results than expected from analytical variablility (coefficient of variation approximately 2%). Fructosamine results obtained on plasma samples drawn at different times of the day differed by up to 1 mmol/l, corresponding to a coefficient of variation of greater than 10%. As a consequence, the information concerning averaged glycaemia of a fructosamine determination is subject to an uncertainty of 7.8 mmol/l. Fructosamine concentrations were linearly related to the protein concentration. Correction for the protein concentration decreased this variability; however, factors other than protein concentration, such as lipid content, also influence results of fructosamine determinations.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00277323
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