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  • 1
    Electronic Resource
    Electronic Resource
    Correspondence; Silicon Determination in Ashed Plant Material (1957)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 5 (1957), S. 872-872 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf60081a010
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The “Inflexible” (1877)
    [s.l.] : Nature Publishing Group
    Nature 16 (1877), S. 247-248 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] MY attention has been called to an article on the Inflexible in NATURE (vol. xvi, p. 201), and I shall be much obliged by your inserting a few remarks, which I shall make as short as possible. On the general subject of the article I do not propose, nor would it be proper for me, to say a word. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/016247a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Role of P-Glycoprotein on the CNS Disposition of Amprenavir (141W94), an HIV Protease Inhibitor (1999)
    Springer
    Pharmaceutical research 16 (1999), S. 1206-1212 
    Details
    ISSN: 1573-904X
    Keywords: ritonavir ; whole-body autoradiography ; blood-brain barrier ; cytochrome P450 ; Caco-2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. To determine the role of P-glycoprotein (Pgp) on the CNS penetration of the HIV protease inhibitor (PI) amprenavir (141W94) and to test the hypothesis that co-administration of a second HIV PI (ritonavir) could enhance amprenavir's brain penetration in vivo. Methods. Pgp-mediated efflux was investigated in vitro with Caco-2 cells and in vivo by whole-body autoradiography (WBA). 'Genetic'mdrla/lbdouble knockout mice, 'chemical' Pgp knockout mice generated by administration of the Pgp inhibitor GF120918, and mice pretreated with ritonavir were used in WBA studies to investigate the effects of Pgp modulation on the CNS penetration of amprenavir. Results. Amprenavir, indinavir, ritonavir, and saquinavir had 2-to 23-fold higher transport rates from the basolateral to apical direction than from the apical to basolateral direction across Caco-2 monolayers. Incubation with GF 120918 negated this difference, suggesting that the efflux was Pgp-mediated. WBA studies demonstrated a 13- and 27-fold increase in the brain and a 3.3-fold increase in the CSF concentrations of amprenavir in mice pretreated with GF120918 and in mdrla/lbdouble knockout mice. In contrast, pretreatment with ritonavir did not alter the CNS exposure of amprenavir. Conclusions. These results provide evidence that amprenavir and other HIV PIs are Pgp substrates and that co-administration of a specific Pgp inhibitor will enhance amprenavir's CNS penetration in vivo. These results will have an important therapeutic impact in the treatment of AIDS dementia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018941328702
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    Paper (German National Licenses)
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