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  • 1
    Electronic Resource
    Electronic Resource
    Class III β-tubulin immunoreactive intranuclear inclusions in human ependymomas and gangliogliomas (2000)
    Springer
    Acta neuropathologica 100 (2000), S. 427-434 
    Details
    ISSN: 1432-0533
    Keywords: Key words Ependymoma ; Ganglioglioma ; Immunohistochemistry ; Intranuclear inclusions ; Tubulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have observed intranuclear inclusion bodies immunoreactive for the cytoskeletal protein class III β tubulin (C3βT) in neurons and ependymal cells of post-mortem human brain. The relationship of these inclusions, detected by light microscopy, to the intranuclear rodlets described by the classical microscopists is unknown. The present study was conducted to determine whether these proteinaceous inclusions (C3βT-NIIs) exist in the neoplastic counterparts of these cell types. Immunohistochemical staining for C3βT revealed intensely stained, predominantly rod-shaped intranuclear inclusions in a variable proportion of tumor cells in five of ten ependymomas. In addition, C3βT-NIIs were encountered in less than 1% of neuronal cells in two of five gangliogliomas. This study represents the first report of tubulin-containing intranuclear inclusions in brain tumors. The functional significance of these inclusions in normal human brain and in cerebral neuroepithelial neoplasms remains to be determined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010000191
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  • 2
    Electronic Resource
    Electronic Resource
    NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia (2006)
    [s.l.] : Nature Publishing Group
    Nature 439 (2006), S. 988-992 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Central nervous system myelin is a specialized structure produced by oligodendrocytes that ensheaths axons, allowing rapid and efficient saltatory conduction of action potentials. Many disorders promote damage to and eventual loss of the myelin sheath, which often results in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature04474
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    Paper (German National Licenses)
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