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  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical study of chromogranin in 100 cases of pheochromocytoma, carotid body tumour, medullary thyroid carcinoma and carcinoid tumour (1988)
    Springer
    Virchows Archiv 413 (1988), S. 33-38 
    Details
    ISSN: 1432-2307
    Keywords: Chromogranin ; Pheochromocytoma ; Medullary thyroid carcinoma ; Carcinoid tumour ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neuroendocrine cells have histologically common features represented by argyrophilic cytoplasm containing neuroendocrine granules. Neuroendocrine granules are composed of various kinds of peptide hormones, amines, carrier proteins and ATP. Although various kinds of peptide hormones have been detected in neuroendocrine tumours, a peptide hormone has not been required as a standard marker for these tumours. Chromogranin is a purified protein which binds catecholamines specifically and is recognized as a carrier protein. We carried out an immunohistochemical study of chromogranin immunoreactivity in 100 neuroendocrine tumours including pheochromocytomas, carotid body tumours, medullary thyroid carcinomas and carcinoid tumours. Marked immunoreactivity was observed in 85% of carcinoid tumours and 100% of the other tumour types. A non-functioning paraganglioma and a malignant carcinoid tumour without any other detectable marker also showed strong immunoreactivity to chromogranin. Chromogranin immunoreactivity is a useful tool for neuroendocrine tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00844279
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    On the influence of nor-adrenaline upon the blood pressure of workers exposed to nitroglycol and the change of the concentration of nor-adrenaline and adrenaline in the urine (1963)
    Springer
    International archives of occupational and environmental health 20 (1963), S. 311-315 
    Details
    ISSN: 1432-1246
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusions 1. As the results of nor-adrenaline (N-A) test, both the duration of blood pressure rise and its degree are less in Nitroglycol (Ng) workers than the control group. 2. N-A excretion in the urine of the Ng group has a tendency to be less than the control group. 3. Judging from the results of the N-A test and N-A excretion in the urine, it may be said that the disturbance in the hypothalamus is playing a main part of the mechanisms of Ng-poisoning. This disturbance causes the same symptom as in diencephalopathia vascularis. 4. It may be thought that the N-A test and the measurement of N-A in the urine are useful as a means for the prophylaxis of Ng poisoning.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00399177
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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