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Cerebrospinal fluid biopterin and biogenic amine metabolites during oral R-THBP therapy for infantile autism (1995)

Komori, Hironori ; Matsuishi, Toyojiro ; Yamada, Shigeto ; [et al.]

Springer

Journal of autism and developmental disorders 25 (1995), S. 183-193

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ISSN: 1573-3432

Source: Springer Online Journal Archives 1860-2000

Topics: Psychology

Notes: Abstract Treatment with 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP) has been suggested to improve autistic behavior. Cerebrospinal fluid (CSF) levels of total biopterin, oxidized and reduced forms of biopterin, homovanillic acid, and 5-hydroxyindoleacetic acid were measured in 14 autistic children and 18 controls to clarify the mechanism of action of R-THBP. The 14 autistic children received R- THBP orally at 1 mg/kg per day; 7 children showed clinical improvement (responders) and the other 7 patients did not (nonresponders). There were no significant differences between responders, nonresponders, and controls in the CSF levels of the metabolites before R- THBP administration. When lumbar puncture was repeated in 6 autistic children in the 24th week of R-THBP therapy, there was no significant change in the CSF levels of any metabolites.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02178503

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Field desorption mass spectrometric measurement of picomole amounts of leucine enkephalin in canine spinal cord tissue (1983)

Desiderio, Dominic M. ; Yamada, Shigeto

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 10 (1983), S. 358-362

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ISSN: 0306-042X

Keywords: Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Leucine enkephalin is measured in canine spinal cord tissue in a structurally unambiguous manner. A rapid tissue procurement procedure minimizes enkephalin metabolism. High-performance liquid chromatography purification of brain neuropeptides is followed by field desorption mass spectrometric measurement of leucine enkephalin in spinal cord tissue extracts. Quantification is performed at the 70 ng (126 pmol) g-1 of wet weight tissue, or 70 parts per billion level. The higher homolog of leucine enkephalin, 2ala-leucine enkephalin, is utilized as internal standard. Straight-line statistics are obtained for a series of samples to which a peptide standard is added.

Additional Material: 4 Ill.