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  • 1
    Electronic Resource
    Electronic Resource
    The relationship between the expression of blood group-related antigens and the cell proliferation of pancreatic carcinomas induced by N-nitrosobis(2-oxopropyl)amine in hamsters (1993)
    Springer
    Surgery today 23 (1993), S. 908-916 
    Details
    ISSN: 1436-2813
    Keywords: pancreatic carcinoma ; blood group-related antigens ; bromodeoxyuridine ; N-nitrosobis(2-oxopropyl)amine ; Syrian golden hamster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between expression of blood group-related antigens (BGRAs) A, B, H, and cell proliferation was investigated during pancreatic carcinogenesis and in transplanted pancreatic carcinomas induced by N-nitrosobis(2-oxopropyl)amine in hamsters. Immunohistochemical staining was performed using monoclonal antibodies (MoAbs) against BGRAs A, B, H, and bromodeoxyuridine (BrdU). The labeling index (LI) was determined as the ratio of the number of BrdUlabeled cells to the total number of cells counted in each lesion. During carcinogenesis, the LI was observed to increase in line with the increase in the extent of atypism (P〈0.01). The mean LIs of the hyperplasia, atypical hyperplasia, and carcinoma were 0.32, 3.21, and 10.2, respectively. The mean LIs of transplanted carcinomas were higher than those of the original carcinomas (P〈0.01). The reactivity with each of the antibodies was determined using an arbitrary scoring system. Staining with MoAbs A and B (staining intensity; 1+ to 3+) appeared to be more intense than that with MoAb H (1+ to 2+) during carcinogenesis. Regarding the growth rate, which was very high, in the transplanted carcinomas, MoAb A reacted with all the cancer cells (4+), whereas, MoAbs B and H reacted with fewer cells (1+ to 3+). These results indicate that the A antigen in particular is associated with the cell proliferation of pancreas, especially with carcinoma induced in hamsters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311371
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  • 2
    Electronic Resource
    Electronic Resource
    Experimental glomerulonephritis induced by a low dose of anti-thy-1 antibody (1997)
    Springer
    Clinical and experimental nephrology 1 (1997), S. 99-109 
    Details
    ISSN: 1437-7799
    Keywords: Thy-1 nephritis ; mild mesangial proliferation ; mesangiolysis ; angiogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background Thy-1.1 nephritis is a widely used model of proliferative glomerulonephritis. Lesions are characterized by diffuse mesangiolysis and prominent ballooning of capillary loops, followed by severe mesangial proliferation. However, such severe lesions are not common in human mesangial proliferative nephritis. We analyzed mild-to-moderate mesangial proliferative nephritis induced by a lower dose of anti-Thy-1.1 antibody. Methods We administered a low intravenous dose (0.02 mg/mL) of antibody to Wislar rats, and the histologic changes were observed by light and electron microscopy and by various immunopathologic methods. The serum complement level and distribution of polymorphonuclear leukocytes were also examined. Results Diffuse mesangial-cell lysis occurred at day 1, but mesangial-matrix lysis was mild, and ballooning of capillary loops was rare. Mesangial cell proliferation appeared at day 2 and reached its maximum at day 5, but it was milder than that seen in the usual dose (0.2 mg/mL) model. The glomerulus was repaired to almost normal structure by day 14. Residual mesangial matrices and endothelial cells seemed to prevent ballooning by making bridges with capillary basement membranes. In the healing stage, this low-dose model demonstrated mild vascular remodeling without active angiogenesis, while the usual-dose model of Thy-1 nephritis showed prominent angiogenic activity to reconstruct capillary tufts. Conclusion The low-dose model of Thy-1 nephritis, which does not require prominent angiogenesis, may be more useful in analyzing the mechanism of glomerulonephritis than the usually adopted Thy-1 nephritis model, which showed drastic glomerular destruction and prominent angiogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02479908
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  • 3
    Electronic Resource
    Electronic Resource
    Dysplastic glomerulocystic kidney (1999)
    Springer
    Clinical and experimental nephrology 3 (1999), S. 51-53 
    Details
    ISSN: 1437-7799
    Keywords: Key words Renal cyst ; Glomerulocystic kidney ; Renal dysplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A female infant presented with renal insufficiency at age 4 weeks. She had bilateral multiple renal cysts but no other malformations of the urinary tract and no family history of renal disease. The kidney, liver, and spleen were not enlarged. Pathology examination of her left kidney when she was 6 years old revealed numerous cortical cysts with a dilatated Bowman's space and small glomerular tufts, and immature metanephric cells which often formed primitive ducts, suggesting a diagnosis of dysplastic glomerulocystic kidney. Glomerulocystic kidney is a rare type of congenital renal cystic disease with various clinical features and etiologies. It must be considered in the differential diagnosis of cystic diseases in infancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101570050009
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  • 4
    Electronic Resource
    Electronic Resource
    Three-dimensional analysis of increased vasculature around the glomerular vascular pole in diabetic nephropathy (1993)
    Springer
    Virchows Archiv 423 (1993), S. 201-207 
    Details
    ISSN: 1432-2307
    Keywords: Diabetic nephropathy ; Glomerular vascular pole ; Neoangiogenesis ; Computer graphics ; Three-dimensional reconstruction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In diabetic nephropathy, several small vessels are frequently observed around the glomerular vascular pole in addition to the usual afferent and efferent arterioles. To elucidate the morphology of these abnormal small vessels, a three-dimensional study was performed by using computer-aided reconstruction techniques. In the present study, the renal tissue samples of 21 biopsy and 73 autopsy cases of diabetic glomerulonephropathy were examined. In addition to ordinary light microscopic observations, three series of serial sections from one autopsy and two biopsy cases were analysed. Five glomeruli with increased numbers of vessels around the vascular pole were reconstructed three-dimensionally. The vasculature in and around the glomerulus was analysed in detail by rotating and viewing in different planes via computer-generated three-dimensional images. These vessels anastomose to the lobular structure of the intraglomerular capillary network, mainly to the afferent branches through the widened vascular hilus. The distal end of the vessels anastomoses to the peritubular capillary. The increased vasculature is interpreted as neoangiogenesis resulting from diabetes, which may have a functional role in facilitating efferent blood flow from the glomerulus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01614771
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  • 5
    Electronic Resource
    Electronic Resource
    Development of the glomerular mesangium (1988)
    Springer
    Pediatric nephrology 2 (1988), S. 85-91 
    Details
    ISSN: 1432-198X
    Keywords: Kidney development ; Glumerulogenesis ; Glomerular mesangium ; Pericyte ; Actin ; Type IV collagen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The development of the glomerular mesangium was studied in fetal and newborn rat kidneys by using a widefield electron microscope which can cover a whole glomerulus within one low-power viewfield. A three-dimensional observation of the immature glomeruli was done by performing ultrathin serial sectionings of the specimen for electron microscopy. Scanning electron microscopic observation of the developing glomeruli was also performed. The developmental distribution of contractile protein (actin) in mesangial cells and the main intrinsic component of the extracellular matrix protein (type IV collagen) of the mesangium were examined by immunohistological techniques. The widefield electron micrograph revealed a precise relationship between the mesangium and other components of the glomerulus. The results confirmed that the capillary extends into the S-shaped body from the sur-rounding vascular system at the initiation of nephronogenesis. The mesangial cells are always continuous to the vascular pericyte-smooth muscle cell system during the whole course of glomerular development and they participate in the sub-division of the capillary network during glomeru-logenesis. Morphological findings and the changing distribution of intra- and extracellular proteins of the mesangium during development suggest that the mesangial cell differentiates from the primitive pericyte of the immature capillary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00870386
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