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  • 1
    Electronic Resource
    Electronic Resource
    Polymers Derived from Carbon Dioxide and Carbonates (1979)
    s.l. : American Chemical Society
    Industrial and engineering chemistry 18 (1979), S. 249-252 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/i360072a004
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  • 2
    Electronic Resource
    Electronic Resource
    Asymmetric reduction of prochiral aromatic ketones with modified reagents prepared from sodium borohydride and carboxylic acids in the presence of 1,2:5,6-di-O-isopropylidene-.alpha.-D-glucofuranose (1980)
    s.l. : American Chemical Society
    The @journal of organic chemistry 45 (1980), S. 4231-4233 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo01309a036
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  • 3
    Electronic Resource
    Electronic Resource
    Asymmetric reduction of ketones with sodium borohydride in the presence of hydroxymonosaccharide derivatives (1979)
    s.l. : American Chemical Society
    The @journal of organic chemistry 44 (1979), S. 1720-1722 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo01324a033
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  • 4
    Electronic Resource
    Electronic Resource
    31P-NMR magnetization transfer study of reperfused rat heart (1993)
    Springer
    Molecular and cellular biochemistry 119 (1993), S. 121-127 
    Details
    ISSN: 1573-4919
    Keywords: saturation transfer ; nuclear magnetic resonance ; reperfused heart ; high-energy phosphate ; ATP ; creatine phosphate ; inorganic phosphate ; cardiac performance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The relationships between pressure rate product (PRP) and flux(PCr → ATP) or flux(Pi → ATP) were studied in isolated perfused rat hearts by the method of saturation transfer using31P-NMR during the preischemic and reperfusion periods. The hearts were made ischemic for 15 min, followed by 60 min of reperfusion. PRP was almost completely depressed, and recovered to 60^ of the control level (preischemic period) after reperfusion. The ATP level during reperfusion was significantly decreased, whereas there was no significant change in PCr level. Pi level of reperfused hearts was significantly higher than that in the control. Both flux(PCr → ATP) and flux(Pi → ATP) were significantly decreased during the reperfusion period (both p〈0.05). However, the flux(PCr → ATP)/PRP ratio during reperfusion did not differ from that of the control. This result indicates that the decrease in flux(PCr → ATP) was matched by a similar decrease in cardiac performance. In contrast, the flux(Pi → ATP)/PRP ratio during reperfusion was significantly decreased compared to that of control. These results suggest that the stunned heart needs less ATP turnover in proportion to its depressed contractile activity, and flux(Pi → ATP) may limit the recovery of postischemic performance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00926862
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  • 5
    Electronic Resource
    Electronic Resource
    Verapamil induced reduction of the myocardial β-adrenoceptor density in BIO 14.6 cardiomyopathic Syrian hamsters (1993)
    Springer
    Molecular and cellular biochemistry 121 (1993), S. 59-65 
    Details
    ISSN: 1573-4919
    Keywords: cardiomyopathy ; upregulation ; downregulation ; norepinephrine ; β-adrenoceptor density
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract In general, it is recognized that prolonged exposure to catecholamine leads to a reduction in the β-adrenoceptor density (downregulation). However, it has been previously reported that the myocardial β-adrenoceptor densities and norepinephrine levels significantly increase in the hearts of BIO 14.6 cardiomyopathic hamsters in the early stage. The mechanism of the increased β-adrenoceptor density is not clearly elucidated, and it can not be excluded that this phenomenon may be a secondary effect. The purpose of this study was to assess the effect of verapamil on the density of β-adrenoceptors in the heart of BIO 14.6 cardiomyopathic hamsters. The total number of β-adrenoceptors in untreated BIO 14.6 hamsters was significantly higher at 90 days of age (30.4±2.2 v.s. 25.9±1.4 fmol/mg protein, p〈0.05). BIO 14.6 hamsters received daily intraperitoneal injections of 5 mg/kg verapamil for 70 days, from an age of 20 days. Verapamil protected against progressive myocardial damage (total damage; 8.2±0.7 v.s. 0.4±0.2%/area, p〈0.05) and the myocardial β-adrenoceptor density returned to that of the normal control group (26.9±3.0 fmol/mg protein). Conversely, verapamil did not have an effect on the number of myocardial β-adrenoceptors in normal golden hamsters. This study showed that verapamil protected against progressive myocardial damage and myocardial β-adrenoceptor density returned to those of normal hamsters. These results suggest that an increased number of β-adrenoceptors in the early stage of BIO 14.6 cardiomyopathic hamsters may be involved in the secondary pathogenesis of cardiomyopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00928700
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  • 6
    Electronic Resource
    Electronic Resource
    Oxygen free radicals and calcium homeostasis in the heart (1994)
    Springer
    Molecular and cellular biochemistry 135 (1994), S. 99-108 
    Details
    ISSN: 1573-4919
    Keywords: sarcolemma ; myofibrils ; Na+/Ca2+ exchange ; sarcoplasmic reticulum ; cardiac contraction ; Ca2+ pump
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Many experiments have been done to clarify the effects of oxygen free radicals on Ca2+ homeostasis in the hearts. A burst of oxygen free radicals occurs immediately after reperfusion, but we have to be reminded that the exact levels of oxygen free radicals in the hearts are yet unknown in both physiological and pathophysiological conditions. Therefore, we should give careful consideration to this point when we perform the experiments and analayze the results. It is, however, evident that Ca2+ overload occurs when the hearts are exposed to an excess amount of oxygen free radicals. Though ATP-independent Ca2+ binding is increased, Ca2+ influx through Ca2+ channel does not increase in the presence of oxygen free radicals. Another possible pathway through which Ca2+ can enter the myocytes is Na+−Ca2+ exchanger. Although, the activities of Na+−K+ ATPase and Na+−Ca2+ exchanger. Although, the activities of Na+−H+ exchange are inhibited by oxygen free radicals, it is not known whether intracellular Na+ level increases under oxidative stress or not. The question has to be solved for the understanding of the importance of Na+−Ca2+ exchange in Ca2+ influx process from extracellular space. Another question is ‘which way does Na+−Ca2+ exchange work under oxidative stress? Net influx or efflux of Ca2+?’ Membrane permeability for Ca2+ may be maintained in a relatively early phase of free radical injury. Since sarcolemmal Ca2+-pump ATPase activity is depressed by oxygen free radicals, Ca2+ extrusion from cytosol to extracellular space is considered to be reduced. It has also been shown that oxygen free radicals promote Ca2+ release from sarcoplasmic reticulum and inhibit Ca2+ sequestration to sarcoplasmic reticulum. Thus, these changes in Ca2+ handling systems could cause the Ca2+ overload due to oxygen free radicals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00925965
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  • 7
    Electronic Resource
    Electronic Resource
    Galectins-1 and -3 and their ligands in tumor biology (1999)
    Springer
    Journal of cancer research and clinical oncology 125 (1999), S. 461-474 
    Details
    ISSN: 1432-1335
    Keywords: Key words Cell adhesion ; Galectin ; Lectin ; Liposome ; Matrix glycoproteins ; Metastasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Protein (lectin)-carbohydrate (cellular glycoconjugate) recognition is operative in biochemical information transfer. Galectins constitute a family of endogenous galactoside-binding lectins with conserved features in the binding site. The members of this lectin category are assumed to be involved in cell adhesion and growth regulation. To assess to what extent the different modes of binding-site presentation and/or carbohydrate fine-specificities will affect aspects of galectin behavior, homodimeric cross-linking galectin-1 and monomeric chimeric galectin-3, with its collagenase-sensitive stalk linked to the carbohydrate-recognition domain, were investigated. Cell-surface expression of the two galectins and accessible galectin-binding sites on various tumor cell lines was ascertained by FACScan analysis. In particular, ligand accessibility for the two galectins differed for the tested cell line types. Binding of tumor cells to laminin and plasma or placental fibronectin was generally reduced by treatment of cells or matrix with galectins. Galectin-3 was more efficient than galectin 1 at impairing laminin's potency as matrix. Cell binding of galectin-1, on the other hand, proved on average more effective for blocking cell association to fibronectins after its preincubation with cell suspensions. Differences were also apparent in the biodistribution of the galectins, where an avian homolog of galectin-1 served as the control to distinguish effects of spatial and sugar-binding features. Histopathological analysis of lymph-node-negative and -positive breast and colorectal carcinomas (n = 180 including 60 metastatic lesions) indicated a correlation of either increased galectin-1 binding and reduced galectin-3 expression or reduced binding of both galectins with the occurrence of lymph node lesions. Together with data on the heparin-binding lectin, revealing reduced expression to be associated with a positive lymph-node status in the breast cancer group, these results can be interpreted to reflect cell-type-dependent requirements of galectin ligand presentation during the metastatic cascade. By introducing mammalian lectins to lectin-histochemical studies, the detection of quantitative differences in glycosylation brings an understanding of its cell biological significance one step closer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004320050303
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  • 8
    Electronic Resource
    Electronic Resource
    Decarboxylation of the 6-nitrobenzisoxazole-3-carboxylate anion catalyzed by cross-linked poly(4-vinylpyridinium) salts (1980)
    Springer
    Polymer bulletin 2 (1980), S. 269-274 
    Details
    ISSN: 1436-2449
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary Catalysis of cationic polyelectrolytes for the decarboxylation of 6-nitrobenzisoxazole-3-carboxylate anion was studied in a buffer solution (pH=9.0). Cross-linked poly (4-vinylpyridinium) salts prepared from 4-vinylpyridine and α, ω -dibromides were used as cationic catalysts. The cross-linked catalysts were found to accelerate markedly the decarboxylation in comparison with the linear water-soluble analogues. Effect of the polymer structure such as the length of (CH2)x linkages between positive charges on the catalytic activity was examined. It was suggested that the acceleration by the cross-linked polymer catalysts would be due to the hydrophobic microenvironment around the catalytic sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00282285
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  • 9
    Electronic Resource
    Electronic Resource
    Preparation of homo- and co-dimers of styrene derivatives using phosphate (1980)
    Springer
    Polymer bulletin 3 (1980), S. 219-224 
    Details
    ISSN: 1436-2449
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary Dimers were preferably obtained in the oligomerization of styrene derivatives by diphenyl hydrogen phosphate. The reaction was assumed to proceed through the formation of esters from the monomers and diphenyl hydrogen phosphate as intermediate. This assumption was confirmed by the fact that treatment of the esters with alternative styrene derivatives gave linear codimers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291960
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  • 10
    Electronic Resource
    Electronic Resource
    Preparation of co-dimers of styrene and p-chlorostyrene with regulated monomer sequences using phosphates (1983)
    Springer
    Polymer bulletin 9 (1983), S. 487-494 
    Details
    ISSN: 1436-2449
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary Two co-dimers of styrene and p-chlorostyrene having regulated monomer sequences were obtained by the reactions of 1-(4-chlorophenyl) ethyl diphenyl phosphate with styrene and of 1-phenylethyl diphenyl phosphate with p-chlorostyrene. The structures of the co-dimers were confirmed by GC-MS and analyses of the oxidative cleavage products.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265233
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