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  • 1
    Digitale Medien
    Digitale Medien
    South-Song stone anchors in China, Korea and Japan (1990)
    Oxford, UK : Blackwell Publishing Ltd
    The @international journal of nautical archaeology 19 (1990), S. 0 
    Details
    ISSN: 1095-9270
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Klassische Archäologie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1095-9270.1990.tb00242.x
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  • 2
    Digitale Medien
    Digitale Medien
    Smooth Muscle And Endothelial Function Of Arterial Grafts For Coronary Artery Bypass Surgery (2002)
    Oxford, UK : Blackwell Science Pty
    Clinical and experimental pharmacology and physiology 29 (2002), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. Various small/mid-sized conductance arteries have been used for coronary artery bypass grafting as arterial grafts, but unanimous opinion to the best use of these grafts has not been formed.2. Arterial grafts are not uniform in their biological characteristics.3. The differences among the arteries may involve the contractility of the vessel. Based on studies of the contractility of arterial grafts, a clinical classification was formed to describe the tendency of vasospasm in the arterial grafts.4. The differences among arterial grafts also involve endothelial function. This refers to both nitric oxide release from the endothelium, as well as endothelium-derived hyperpolarizing factor-mediated hyperpolarization and relaxation.5. The difference in the peri-operative behaviour of the grafts and in their long-term patency may be related to different characteristics. These should be taken into account in the use of arterial grafts, some of which are subject to more active pharmacological intervention during and after operation to obtain satisfactory results. The clinical choice of grafts must be based on the general condition of the patient, the biological characteristics of the graft, the anatomy of the coronary artery, the match between the coronary artery and the graft and the technical considerations, including antispastic management.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1440-1681.2002.03705.x
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  • 3
    Digitale Medien
    Digitale Medien
    Procaine in Cardioplegia: The Effect on EDHF-Mediated Function in Porcine Coronary Arteries (2001)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiac surgery 17 (2001), S. 0 
    Details
    ISSN: 1540-8191
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract  Objectives: Hyperkalemia in cardioplegia impairs the endothelium-derived hyperpolarizing factor (EDHF)-mediated function. This study examined the effect of procaine in cardioplegia on the EDHF-mediated response in porcine coronary arteries. Methods: An isometric force study was performed in a myograph. Two rings taken from the same artery (diameter 200–450 μm) were incubated with Krebs solution (group I) or 20 mM K+ (group II) with/without procaine (1 mM) at 37°C for 1 hour. The EDHF-mediated relaxation was induced by bradykinin (BK,-10 ˜-6.5 log M) after U46619 (-8 log M, in group I) or K+-precontraction (in group II) in the presence of indomethacin (7 μM), NG-nitro-L-arginine (300 μM), and hemoglobin (20 μM). The membrane potential of a single smooth muscle cell was measured by a microelectrode after superfusion with Krebs solution with/without procaine for 1 hour. Results: The EDHF-mediated relaxation was increased by the treatment with procaine with the EC50 shifted leftward (97.3 ± 0.6% vs. 83.0 ± 5.1% at-7 log M and 99.4 ± 0.6% vs. 96.7 ± 1.6% at-6.5 log M, p 〈 0.05; EC50.-8.57 ± 0.24 vs.-7.92 ± 0.23 log M, p 〈 0.05). Procaine decreased the BK-induced hyperpolarization from-72.3 ± 0.7 mV to-68.8 ± 0.8 mV (-6.5 log M, p 〈 0.01). The EDHF-mediated relaxation in arteries exposed to 20 mM K+ was not altered by procaine (49.9 ± 7.4% vs. 55.8 ± 7.6%, p 〉 0.05). Conclusions: In the coronary arteries, procaine has a depolarizing effect but it enhances EDHF-mediated relaxation. Addition of procaine in cardioplegia did not change the EDHF-mediated endothelial function.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1540-8191.2001.tb01180.x
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  • 4
    Digitale Medien
    Digitale Medien
    Impaired EDHF-Mediated Relaxation in Porcine Pulmonary Micro-Arteries by Cold Storage with University of Wisconsin and Euro-Collins Solutions (2002)
    350 Main Street , Malden , MA 02148 , USA. , and 9600 Garsington Road , Oxford OX4 2DQ , England . : Blackwell Science Inc
    Journal of cardiac surgery 17 (2002), S. 0 
    Details
    ISSN: 1540-8191
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background: Vascular endothelium plays a key role in regulation of vascular tone. Hyperkalemia has been demonstrated to impair the EDHF-mediated endothelial function in coronary circulation. University of Wisconsin (UW) and Eruo-collins (EC) solutions are used for organ preservation in transplantation surgery. The potassium concentration in UW or EC solutions is as high as 125 mmol/L or 115 mmol/L, respectively. This study was designed to examine whether hyperkalemia or storage with UW and EC solutions affects the relaxation mediated by EDHF in the porcine pulmonary micro-arteries. Methods: Porcine pulmonary micro-artery rings (diameter 200–450 μm) were studied in myograph (n = 8 in each group). After incubation with hyperkalemia (K+ 125 mmol/L, at 37° C), UW or EC solutions (at 4° C for 4 hours), EDHF-mediated relaxation induced by bradykinin (BK, −10 to −6.5 log M) in the presence of inhibitors for cyclooxygenase (Indomethacin, 7 μM), nitric oxide synthase (NG-nitro-L-arginine, 300 μM), and oxyhemoglobin (20 μM) was compared with control (Krebs' solution) in precontraction with U46619 (−7.5 log M). Results: The EDHF-mediated relaxation to BK was 69.6 ± 6.3% compared with 97.1 ± 1.7% (p= 0.003) in control (no inhibitors). After incubation with hyperkalemia, the relaxation significantly decreased (38.6 ± 3.0% vs. 59.1 ± 7.4%, p= 0.03). Storage with UW or EC solutions also significantly decreased the relaxation (49.3 ± 7.3% vs. 65.2 ± 3.5%, p= 0.04 and 51.9 ± 8.4% vs. 60.3 ± 6.1%, p= 0.02, respectively). Conclusions: In porcine pulmonary micro-arteries, exposure to hyperkalemia or storage with UW or EC solutions at 4°C for 4 hours impairs the EDHF-mediated endothelial function. The clinical significance of this effect should be further studied.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1540-8191.2002.10147.x
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  • 5
    Digitale Medien
    Digitale Medien
    Different Role of Epoxyeicosatrienoic Acids (EET11,12) in Endothelium-Derived Hyperpolarizing Factor-Mediated Relaxation in Porcine Coronary and Pulmonary Micro-Arteries (2002)
    350 Main Street , Malden , MA 02148 , USA. , and 9600 Garsington Road , Oxford OX4 2DQ , England . : Blackwell Science Inc
    Journal of cardiac surgery 17 (2002), S. 0 
    Details
    ISSN: 1540-8191
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Objectives: Endothelium-derived hyperpolarizing factor (EDHF) plays a key role in vasorelaxation and the cytochrome P450-monooxygenase metabolites of arachidonic acid epoxyeicosatrienoic acids (EETs), such as EET11,12, have been suggested to be EDHF in various vasculatures. However, little is known about the role of EET11,12 in the coronary and pulmonary circulation, especially in microcirculation. The present study was designed to examine the role of EET11,12 in porcine coronary and pulmonary micro-arteries. Methods: Porcine coronary and pulmonary micro-arteries (diameter 200-450 μm) were studied in a myograph (n = 8 in each group). The artery rings were set at the 90% of the circumference at 100 mm Hg for coronary or 30 mm Hg for pulmonary micro-arteries, respectively. After precontraction with U46619 (−8.2 log M for coronary and −7.5 log M for pulmonary micro-arteries), EET11,12 (−10 ∼−6.5 log M) or bradykinin (BK, −10 ∼−6.5 log M)-induced relaxation was established in the presence of inhibitors for cyclooxygenase (indomethacin, 7 μM), nitric oxide (NO) synthetase (NG-nitro-L-arginine, 300 μM), and NO scavenger oxyhemoglobin (20 μM). Results: EET11,12 induced a dose-dependent relaxation in coronary micro-arteries with the maximal relaxation of 18.3 ± 3.3% that was significantly less than the relaxation induced by BK (72.5 ± 7.8%; P 〈 0.001). In contrast, in pulmonary micro-arteries, BK induced a marked relaxation (69.6 ± 6.3%) whereas EET11,12 did not have any effect. Conclusion: In porcine coronary micro-arteries, EET11,12 may partially mimic the action of EDHF whereas in pulmonary arteries, this substance is unlikely involved in the EDHF-mediated relaxation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1540-8191.2002.101433.x
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  • 6
    Digitale Medien
    Digitale Medien
    Procaine in Cardioplegia: Does It Affect the Endothelial Function? (2002)
    350 Main Street , Malden , MA 02148 , USA. , and 9600 Garsington Road , Oxford OX4 2DQ , England . : Blackwell Science Inc
    Journal of cardiac surgery 17 (2002), S. 0 
    Details
    ISSN: 1540-8191
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Objective: Cardioplegic solutions are widely used in cardiac surgery and hyperkelemia in cardioplegia has been demonstrated to impair the endothelium-derived hyperpolarizing factor (EDHF)-mediated endothelial function. The present study examined the effect of procaine in St. Thomas Hospital Cardioplegia on the EDHF-mediated response in porcine coronary arteries. Methods: Isometric force study: Porcine coronary micro-arteries were studied in a myograph. Two rings taken from the same artery (diameter 200–450 μm, n = 8) were incubated with Kreb's solution as control or Kreb's solution plus procaine (1 mM) at 37 °C for 1 h, respectively. The EDHF-mediated relaxation was induced by bradykinin (BK, −10 ∼−6.5 log M) in the presence of indomethacin (Indo, 7 μM), NG-nitro-L-arginine (L-NNA, 300 μM), and hemoglobin (HbO, 20 μM) after U46619-precontraction (−8 log M). Electrophysiological study: The membrane potential of a single smooth muscle cell in coronary arteries was measured by a microelectrode after superfusion with Kreb's solution or Kreb's containing procaine (1 mM) for 1  h. Results: Procaine had little effect on the resting force of porcine coronary micro-arteries (0.94 ± 0.74 mN vs. 0.67 ± 0.23 mN in control, P 〉 0.05) and did not alter the U46619-induced precontraction (10.7 ± 1.7 mN vs. 12.0 ± 1.7 mN, P 〉 0.05). The BK-induced, EDHF-mediated relaxation was increased by the treatment with procaine with the EC50 shifted leftward (97.3 ± 0.6% vs. 83.0 ± 5.1% at −7 log M and 99.4 ± 0.6% vs. 96.7 ± 1.6% at −6.5 log M, P 〈 0.05; EC50: −8.57 ± 0.24 vs. −7.92 ± 0.23 log M, P 〈 0.05). Procaine slightly depolarized the smooth muscle cell (−56.3 ± 1.0 vs. −59.3 ± 0.7 mV, P 〉 0.05) and decreased the BK-induced hyperpolarization from −70.3 ± 0.4 mV to −68.0 ± 0.8 mV (−7 log M, P 〈 0.05) and from −72.3 ± 0.7 mV to −68.8 ± 0.8 mV (−6.5 log M, P 〈 0.01). Conclusions: In the coronary arteries, procaine has depolarizing effect but it enhances the EDHF-mediated relaxation. Therefore, addition of procaine in cardioplegia may preserve the EDHF-mediated endothelial function.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1540-8191.2002.101432.x
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  • 7
    Digitale Medien
    Digitale Medien
    Ultrasonography for Diagnosis of Acute Appendicitis: Results of a Prospective Multicenter Trial (1999)
    Springer
    World journal of surgery 23 (1999), S. 141-146 
    Details
    ISSN: 1432-2323
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/PL00013165
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  • 8
    Digitale Medien
    Digitale Medien
    Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes (2005)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 436 (2005), S. 356-362 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] In obesity and type 2 diabetes, expression of the GLUT4 glucose transporter is decreased selectively in adipocytes. Adipose-specific Glut4 (also known as Slc2a4) knockout (adipose-Glut4-/-) mice show insulin resistance secondarily in muscle and liver. Here we show, using DNA arrays, ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/nature03711
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  • 9
    Digitale Medien
    Digitale Medien
    Fabrication of LaNiO〈sub〉3〈/sub〉 Chain-Like Ceramics from Nanocable Precursors (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 336-338 (Apr. 2007), p. 2179-2181 
    Details
    ISSN: 1013-9826
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Maschinenbau
    Notizen: One-dimensional LaNiO3 nanochains can be generated with high yield by a simple calcinationprocess using La(OH)3/Ni(OH)2 coaxial nanocables as parent template. Those coaxial nanocables can besynthesized by a simple hydrothermal method. The final LaNiO3 ceramics keep the morphology of parentprecursor
    Materialart: Digitale Medien
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.336-338.2179.pdf
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  • 10
    Digitale Medien
    Digitale Medien
    Initiation and regulation mechanisms of ribosomal RNA transcription in the eukaryote Acanthamoeba castellanii (1991)
    Springer
    Molecular and cellular biochemistry 104 (1991), S. 119-126 
    Details
    ISSN: 1573-4919
    Schlagwort(e): DNA melting ; transcription initiation ; footprinting ; RNA polymerase I ; posttranslational modification
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract Acanthamoeba rRNA transcription involves the binding of a transcription initiation factor (TIF) to the core promoter of rDNA to form the preinitiation complex. This complex is formed in the absence of RNA polymerase I, and persists for multiple rounds of initiation. Polymerase I next binds to form the initiation complex. This binding is DNA sequence-independent, and is directed by protein-protein contacts with TIF. DNA melting occurs in a separate step. In contrast to most prokaryotic transcription, melting occurs only following nucleotide addition and β-γ hydrolysis of ATP is not required as for polymerase II. Growth-dependent regulation of rRNA transcription is accomplished by modification of RNA polymerase I. The inactive form of polymerase (PolE) is unable to bind to the promoter and has altered heat stability. PolE is still active in elongation; thus, the modification affects the polymerase site involved in TIF contact. Modification of a polymerases I and III common subunit has been detected leading to the suggestion that transcription of stable RNAs of the ribosome might be co-regulated by this mechanism.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00229811
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