ISSN:
1432-1211
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Although diversity within the HLA-DRB region is predominantly focused in the DRB1 gene, the second expressed DRB loci, DRB3, DRB4, and DRB5, also exhibit variation. Within DRB1 * 15 or DRB1 * 16 haplotypes, four new variants were identified: 1) two new DRB5 alleles, DRB5 * 0104 and DRB5 * 0204, 2) a haplotype carrying a DRB1 * 15 or * 16 allele without the usual accompanying DRB5 allele, and 3) a haplotype carrying a DRB5* 0101 allele without a DRB1 * 15 or * 16 allele. The evolutionary origins of these haplotypes were postulated based on their associations with the DRB6 pseudogene. Within HLA haplotypes which carry DRB3, a new DRB3 * 0205 allele and one unusual DRB3 association were identified. Finally, two new null DRB4 alleles are described: DRB4 * 0201N, which exhibits a deletion in the second exon, and a second allele, DRB4 * null, which lacks the second exon completely. Gene conversion-like events and variation in the number of functional genes through reciprocal recombination and inactivation contribute to the diversity observed in the second expressed HLA-DRB loci.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002510050248
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