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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Biochemistry 13 (1974), S. 5083-5087 
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Molecular and cellular biochemistry 19 (1978), S. 3-6 
    ISSN: 1573-4919
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary Controlled tryptic digestion of purified rat skeletal muscle sarcoplasmic reticulum (Ca2+ + Mg2+)-adenosine triphosphatase yields two products designated Fragments 3a and 3b with molecular weights of 65,000 and 56,000 respectively. The isolation of these products in high yield should facilitate exploration of the molecular characteristics of this adenosine triphosphatase. A simple, rapid method for accomplishing this isolation was developed which provides a high yield and utilizes mild conditions. The fragments obtained by this method were used to determine the phospholipid and sulfhydryl contents of Fragments 3a and 3b. In addition, information was obtained on the orientation of these adenosine triphosphatase components in the enzyme lipoprotein complex.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Age 17 (1994), S. 93-97 
    ISSN: 1574-4647
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It is generally accepted that oxidative stress increases with age, as indicated by age-related increases in lipid peroxidation. Also found in the aged organism is the accumulation of iron in various tissues. The increase in lipid peroxidation and tissue iron accumulation may not have been coincidental, but rather may be a causally related phenomenon, since iron involvement in lipid peroxidation is a well-accepted phenomenon in free radical metabolism. Our present study examined serum iron and ferritin as means to compare age-related changes in lipid peroxides and peroxidizability in aged rats. In addition, the anti-aging effect of dietary restriction on the modulation of iron status and lipid peroxidation was assessed. The results showed that the age-related increase in serum iron concurs with increased lipid peroxidation, and that these adverse changes were effectively attenuated by dietary restriction. Our finding is the first report on the modulation of iron status by long-term calorie restriction, and is consistent with the previous findings on the anti-peroxidative action of dietary restriction.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Age 12 (1989), S. 133-136 
    ISSN: 1574-4647
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Food restriction (FR) was tested for its ability to protect against age-related membrane deterioration of kidney. Mitochondria and microsomes were isolated from male Fischer 344 rats that were either fed ad libitum (AL) or food restricted (60% of ad libitum). The result show the yields of isolated membranes decreased considerably with age in AL fed rats, but much less so in FR rats. Additional information on membrane protection by food restriction came from the analysis of membrane fatty acid composition: the amount of total saturated membrane fatty acid and highly oxidizable arachidonic acid increased in AL rats, and this was effectively modulated by food restriction.
    Type of Medium: Electronic Resource
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